Authors:
Peiyi Song
;
Danny Jian Hang Tng
;
Rui Hu
and
Ken-Tye Yong
Affiliation:
Nanyang Technological University, Singapore
Keyword(s):
Cancer Drug Delivery, Implantable Device, Biocompatibility, in Vitro, in Vivo.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Instrumentation
;
Biomedical Instruments and Devices
;
Hardware
;
Implantable Electronics
;
MEMS
;
Microelectronics
;
Sensor Networks
Abstract:
Cancer patients nowadays suffer from serious side effects and unpleasant experiences when treated with
anti-cancer drugs. Conventional drug delivery methods including drug pills/capsules, topical drug gels/drops
and drug injections are too simple, incapable of providing controllable and efficient tumour drug delivery in
cancer treatment. Implantable drug delivery devices open a new horizon for drug treatment. Through device
implantation locally onto disease site, high efficiency drug delivery can be achieved. Utilizing techniques
from microfluidics, precise manipulation of drug fluids by these devices offer great advances for treatment.
In our study, an electrochemical actuated microfluidic drug delivery device was fabricated and studied in
vitro and in vivo. Cultured pancreatic cancer cell colonies were successfully inhibited by programmable
Doxorubicin treatments controlled by devices. Further, 12 devices were implanted into 12 Kunming mice
for evaluation of biocompatibility and dr
ug delivery performance. Tissue biopsy and blood sample analyses
indicated all 12 mice remaining healthy after devices implantation. Adrenaline was delivered to the
abdominal cavity of the mice by using the implanted device and compared with conventional injection as a
positive control. Both approaches have shown that they are able to precisely control and manipulate the
increment rate of blood pressure in the small animals.
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