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Authors: Edgars Celms ; Lelde Lace ; Gatis Melkus ; Peteris Rucevskis ; Sandra Silina ; Andrejs Sizovs and Juris Viksna

Affiliation: Institute of Mathematics and Computer Science, University of Latvia, Raina Bulvaris 29, Riga, Latvia

Keyword(s): Chromatin Interaction Networks, Graph Representations, Network Topology, Graph Patterns.

Abstract: We present a novel extension of graph representations of chromatin interaction networks incorporating edge directionality and vertex label assignments and focus on patterns defined by different types of 3-cliques that can occur under such assignments. 3-cliques are chosen for their simplicity and comparative ubiquity in chromatin interaction graphs; also, our previous work indicates a certain level of biological significance that can be assigned to them. Here we explore statistical distributions of different types of directionality- and strand-based 3-cliques patterns in two well-curated promoter capture Hi-C data sets and observe that the pattern distributions strongly deviate from random, if they are considered in the context of a number of additional features. These observations provide a good justification for further exploration of chromatin interaction data sets using network representations that include edge directionality and node label assignments and indicate a possibility that these annotation features could be related to some specific underlying biological mechanisms. (More)

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Paper citation in several formats:
Celms, E., Lace, L., Melkus, G., Rucevskis, P., Silina, S., Sizovs, A. and Viksna, J. (2025). Enhanced Graph Representations of Chromatin Interaction Networks. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS; ISBN 978-989-758-731-3; ISSN 2184-4305, SciTePress, pages 579-585. DOI: 10.5220/0013173100003911

@conference{bioinformatics25,
author={Edgars Celms and Lelde Lace and Gatis Melkus and Peteris Rucevskis and Sandra Silina and Andrejs Sizovs and Juris Viksna},
title={Enhanced Graph Representations of Chromatin Interaction Networks},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS},
year={2025},
pages={579-585},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013173100003911},
isbn={978-989-758-731-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS
TI - Enhanced Graph Representations of Chromatin Interaction Networks
SN - 978-989-758-731-3
IS - 2184-4305
AU - Celms, E.
AU - Lace, L.
AU - Melkus, G.
AU - Rucevskis, P.
AU - Silina, S.
AU - Sizovs, A.
AU - Viksna, J.
PY - 2025
SP - 579
EP - 585
DO - 10.5220/0013173100003911
PB - SciTePress

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