Authors:
Eros Montin
1
;
Paolo Potepan
2
and
Luca Mainardi
1
Affiliations:
1
Politecnico di Milano, Italy
;
2
Fond. IRCCS Istituto Nazionale Tumori, Italy
Keyword(s):
Whole Body Imaging, MRI, Myeloma.
Related
Ontology
Subjects/Areas/Topics:
Applications and Services
;
Biomedical Engineering
;
Biomedical Signal Processing
;
Computer Vision, Visualization and Computer Graphics
;
Detection and Identification
;
Medical Image Detection, Acquisition, Analysis and Processing
Abstract:
Objective. In this study we point out the Diffusion-Weighted Imaging (DWI) role in the diagnosis of multiple
myeloma (MM), comparing its signal values (SV) (Sommer et al., 2010) with the standard imaging modalities
T1, T2. We further evaluate how SV change in relation with the percentage of plasma cells infiltration evaluated
through bone marrow biopsy (BMB).
Methods. Since March 2008 23 patients with average age of 61 (+/- 11) years old, 11 females and 12 males,
have been investigated before their own therapy with a whole body MRI protocol, concerning a whole body
T1, a whole body T2 and a whole body DWI and a BMB. An experienced radiologist defined for each patient
two volume of interests (VOIs): onto the main lesions and on healthy bones (Femur and Homerus). After that,
we have subdivided the full population by a clinical threshold of 25% on cells infiltration percentage; then, we
analysed statistical differences in the 2 groups (A, B).
Results. We found out that DWI voxels intens
ities in group A (infiltration <= 25%) were higher than group B,
this gap had to be considered statistically different (P <= 0:05).
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