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Authors: Stephan T. Koev 1 ; Peter H. Dykstra 1 ; Reza Ghodssi 2 ; Gary W. Rubloff 3 ; William E. Bentley 4 and Gregory F. Payne 5

Affiliations: 1 MEMS Sensors and Actuators Lab, Institute for Systems Research, Departement of Electrical and Computer Engineering, University of Maryland, United States ; 2 ~MEMS Sensors and Actuators Lab, Institute for Systems Research, Departement of Electrical and Computer Engineering, University of Maryland, United States ; 3 Institute for Systems Research, Department of Materials Science and Engineering, Univerisity of Maryland, United States ; 4 Fischell Department of Bioengineering, Univerisity of Maryland, United States ; 5 Center for Biosystems Research, University of Mayland Biotechnology Institute, United States

Keyword(s): Chitosan, MEMS, DNA hybridization, Microcantilever, Fluorescence.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instruments and Devices ; Hardware ; MEMS ; Sensor Networks

Abstract: This paper presents the biological functionalization of MEMS sensors by using the polysaccharide chitosan. Chitosan is a unique polymer due to its abundance of primary amine groups and its ability to be electrodeposited with spatial and temporal control. Biomolecules such as DNA and proteins can be attached to chitosan films by standard coupling chemistries. This biofunctionalization approach was demonstrated for two different MEMS devices: a microcantilever and an optical sensor. The devices were coated with chitosan and probe DNA and were used for detecting the hybridization with target DNA. Here, we describe the design, fabrication procedure, and testing results for both of these biosensors.

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Paper citation in several formats:
Koev, S.; Dykstra, P.; Ghodssi, R.; Rubloff, G.; Bentley, W. and Payne, G. (2009). CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors. In Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES; ISBN 978-989-8111- 64-7; ISSN 2184-4305, SciTePress, pages 109-112. DOI: 10.5220/0001552801090112

@conference{biodevices09,
author={Stephan T. Koev. and Peter H. Dykstra. and Reza Ghodssi. and Gary W. Rubloff. and William E. Bentley. and Gregory F. Payne.},
title={CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES},
year={2009},
pages={109-112},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001552801090112},
isbn={978-989-8111- 64-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES
TI - CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors
SN - 978-989-8111- 64-7
IS - 2184-4305
AU - Koev, S.
AU - Dykstra, P.
AU - Ghodssi, R.
AU - Rubloff, G.
AU - Bentley, W.
AU - Payne, G.
PY - 2009
SP - 109
EP - 112
DO - 10.5220/0001552801090112
PB - SciTePress