loading
Papers Papers/2022 Papers Papers/2022

Research.Publish.Connect.

Paper

Paper Unlock

Authors: Malgorzata Kardynska 1 ; Jaroslaw Smieja 1 ; Anna Naumowicz 1 ; Patryk Janus 2 ; Piotr Widlak 2 and Marek Kimmel 3

Affiliations: 1 Silesian University of Technology, Poland ; 2 Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Poland ; 3 Silesian University of Technology and Rice University, Poland

Keyword(s): Sensitivity Analysis, Sloppy Parameters, Signalling Pathways, NF-кB, HSF, HSP.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology

Abstract: Sensitivity analysis methods have been developed for over half a century. However, their application to systems biology is a relatively new concept and has not been fully investigated. In this paperwe focus on creating parameter rankings based on sloppy/stiff parameter sensitivity analysis, that can be used to find the most important parameters and processes (that have the greatest impact on the system output) and subsequently can be used to reduce the number of experiments needed to precisely estimate parameters values or to indicate molecular targets for new drugs. In order to test the proposed procedure we performed sensitivity analysis of the HSF/NF-кB pathway model - a model combining two signaling pathways essential for cell survival.

CC BY-NC-ND 4.0

Sign In Guest: Register as new SciTePress user now for free.

Sign In SciTePress user: please login.

PDF ImageMy Papers

You are not signed in, therefore limits apply to your IP address 3.145.8.2

In the current month:
Recent papers: 100 available of 100 total
2+ years older papers: 200 available of 200 total

Paper citation in several formats:
Kardynska, M.; Smieja, J.; Naumowicz, A.; Janus, P.; Widlak, P. and Kimmel, M. (2016). Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways. In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS; ISBN 978-989-758-170-0; ISSN 2184-4305, SciTePress, pages 278-283. DOI: 10.5220/0005820002780283

@conference{bioinformatics16,
author={Malgorzata Kardynska. and Jaroslaw Smieja. and Anna Naumowicz. and Patryk Janus. and Piotr Widlak. and Marek Kimmel.},
title={Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS},
year={2016},
pages={278-283},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005820002780283},
isbn={978-989-758-170-0},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS
TI - Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways
SN - 978-989-758-170-0
IS - 2184-4305
AU - Kardynska, M.
AU - Smieja, J.
AU - Naumowicz, A.
AU - Janus, P.
AU - Widlak, P.
AU - Kimmel, M.
PY - 2016
SP - 278
EP - 283
DO - 10.5220/0005820002780283
PB - SciTePress

- Science and Technology Publications, Lda.
RESOURCES

Proceedings

Papers

Authors

Ontology

CONTACTS

Science and Technology Publications, Lda
Avenida de S. Francisco Xavier, Lote 7 Cv. C,
2900-616 Setúbal, Portugal.

Phone: +351 265 520 185 (National fixed network call)
Fax: +351 265 520 186
Email: info@scitepress.org

EXTERNAL LINKS

PRIMORIS

INSTICC

SCITEVENTS

CROSSREF

PROCEEDINGS SUBMITTED FOR INDEXATION BY:

dblp

Ei Compendex

SCOPUS

Semantic Scholar

Google Scholar

Microsoft Academic