Authors:
Jorge Guerrero
1
;
Roberto Ambrosio
2
and
Amanda Carrillo
1
Affiliations:
1
Universidad Autonoma de Ciudad Juárez, Mexico
;
2
Universidad Autonoma de Ciudad Juarez, Mexico
Keyword(s):
Biosensor, EnFET, Transducer, Myelin Basic Protein, Multiple Sclerosis.
Related
Ontology
Subjects/Areas/Topics:
Biomaterials
;
Biomedical Engineering
;
Biomedical Instruments and Devices
;
Biomedical Sensors
;
Microelectronics
Abstract:
In this work, the design of a biosensor based on FET technology have been proposed, simulating the
modification to the gate of an Ion Sensitive Field-Effect Transistor (ISFET) with a synthetic polymer to
entrap the desired analyte which contains Myelin Basic Protein (MBP). This analyte is generally used in test
to find out if someone is suffering a demyelinating disease, and is commonly detected by Enzyme Linked
Immunosorbent Assays (ELISA). Based on this principle, we propose a simpler method, fundamented on
Enzyme Field-Effect Transistor (EnFET) technology in order to develop a new device applied to the
diagnosis of demyelinating diseases. Simulation examples are used in order to demonstrate the functionality
for this type of biosensor to its exposure to MBP at concentrations of 10-4 to 10-1 mol/L, where the amount
of analyte in the receptor located at the top of the gate will determine the level of voltage applied to create a
channel and activate the device.