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Authors: T. Savelieva 1 ; D. Kustov 2 ; P. Grachev 1 ; V. Makarov 2 ; E. Osipova 2 and V. Loschenov 1

Affiliations: 1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov st., Moscow, Russia, National Research Nuclear University MEPhI, Kashirskoe sh., Moscow, Russia ; 2 Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov st., Moscow, Russia

ISBN: 978-989-758-364-3

Keyword(s): Indocyanine Green, Protoporphyrin IX, Haemoglobin Oxygenation, Fluorescence, Diffuse Reflectance.

Abstract: Due to the high recurrence rate after the glial brain tumor removal, methods of intraoperative navigation have a high relevance, providing the most complete removal of tumor tissues with maximum preservation of healthy ones. In this work a combined visualization method is proposed with an assessment of fluorescence and diffuse reflectance images. Fluorescence intensity of 5-ALA-induced protoporphyrin IX allows visualization of tumor cells, distribution of indocyanine green fluorescence helps to visualize the vascular system of the tumor, and parallel mapping of the degree of oxygenation demonstrate the hypoxic regions. The images were obtained in the near infrared range of the optical spectrum in order to maximize the optical probing depth in the window of biological transparency.

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Paper citation in several formats:
Savelieva, T.; Kustov, D.; Grachev, P.; Makarov, V.; Osipova, E. and Loschenov, V. (2019). Combined Video Analysis of ICG and 5-ALA Induced Protoporphyrin IX and Hemoglobin Oxygen Saturation in near Infrared.In Proceedings of the 7th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS, ISBN 978-989-758-364-3, pages 320-324. DOI: 10.5220/0007693703200324

@conference{photoptics19,
author={T. A. Savelieva. and D. M. Kustov. and P. V. Grachev. and V. I. Makarov. and E. E. Osipova. and V. B. Loschenov.},
title={Combined Video Analysis of ICG and 5-ALA Induced Protoporphyrin IX and Hemoglobin Oxygen Saturation in near Infrared},
booktitle={Proceedings of the 7th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,},
year={2019},
pages={320-324},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007693703200324},
isbn={978-989-758-364-3},
}

TY - CONF

JO - Proceedings of the 7th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,
TI - Combined Video Analysis of ICG and 5-ALA Induced Protoporphyrin IX and Hemoglobin Oxygen Saturation in near Infrared
SN - 978-989-758-364-3
AU - Savelieva, T.
AU - Kustov, D.
AU - Grachev, P.
AU - Makarov, V.
AU - Osipova, E.
AU - Loschenov, V.
PY - 2019
SP - 320
EP - 324
DO - 10.5220/0007693703200324

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