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Authors: Edward Muliawan Putera ; Iswan Abbas Nusi ; Poernomo Boedi Setiawan ; Herry Purbayu ; Titong Sugihartono ; Ummi Maimunah ; Ulfa Kholili ; Budi Widodo ; Husin Thamrin ; Amie Vidyani and Muhammad Miftahussurur

Affiliation: Department of Internal Medicine, Faculty of medicine Universitas Airlangga, Dr. Soetomo General Hospital and Surabaya, Indonesia

Keyword(s): Antiviral, chronic hepatitis b, ALT, VHB DNA, NA

Abstract: Virus Hepatitis B (VHB) eradication still cannot be achieved under current clinical guidelines due to the typical virus life cycle. Four phases of disease in chronic hepatitis B infection have been used as guidance in preparing therapy indications. Virus suppression with a nucleoside analog (NA) is an important part of chronic hepatitis B therapy, but the high post-termination recurrence rate of NA results in an unlimited duration of therapy. Long-term NA therapy results in various problems such as resistance, reduced adherence, side-effects, and economic burden for patients. The latest findings add to the possibility of larger HBsAg seroconversion after the termination of NA therapy. Various guidelines provide guidance on the termination of NA therapy. It is stated that the termination of NA therapy can be performed using strict surveillance methods for individuals who have undergone antiretroviral therapy after which follows HBeAg seroconversion, minimal amount of VHB DNA, non-cirr hosis status, and normal ALT levels (More)

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Paper citation in several formats:
Putera, E.; Nusi, I.; Setiawan, P.; Purbayu, H.; Sugihartono, T.; Maimunah, U.; Kholili, U.; Widodo, B.; Thamrin, H.; Vidyani, A. and Miftahussurur, M. (2018). Termination of Antiviral Administration in Chronic Hepatitis B. In Proceedings of Surabaya International Physiology Seminar - SIPS; ISBN 978-989-758-340-7; ISSN 2184-3678, SciTePress, pages 431-437. DOI: 10.5220/0007340204310437

@conference{sips18,
author={Edward Muliawan Putera. and Iswan Abbas Nusi. and Poernomo Boedi Setiawan. and Herry Purbayu. and Titong Sugihartono. and Ummi Maimunah. and Ulfa Kholili. and Budi Widodo. and Husin Thamrin. and Amie Vidyani. and Muhammad Miftahussurur.},
title={Termination of Antiviral Administration in Chronic Hepatitis B},
booktitle={Proceedings of Surabaya International Physiology Seminar - SIPS},
year={2018},
pages={431-437},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007340204310437},
isbn={978-989-758-340-7},
issn={2184-3678},
}

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - SIPS
TI - Termination of Antiviral Administration in Chronic Hepatitis B
SN - 978-989-758-340-7
IS - 2184-3678
AU - Putera, E.
AU - Nusi, I.
AU - Setiawan, P.
AU - Purbayu, H.
AU - Sugihartono, T.
AU - Maimunah, U.
AU - Kholili, U.
AU - Widodo, B.
AU - Thamrin, H.
AU - Vidyani, A.
AU - Miftahussurur, M.
PY - 2018
SP - 431
EP - 437
DO - 10.5220/0007340204310437
PB - SciTePress

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