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Authors: Teppo Annila ; Ramakanth Neeli-Venkata and Andre S. Ribeiro

Affiliation: Tampere University of Technology, Finland

Keyword(s): Protein Cluster, Tsr Proteins, Cluster Localization, Microscopy.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Computational Molecular Systems ; Systems Biology

Abstract: Clustering and positioning of chemotaxis-associated proteins are believed to be essential steps for their proper functioning. We investigate the robustness of these processes to sub-optimal temperatures by studying the size and location of clusters of Tsr-Venus proteins in live cells. We find that the degree of clustering of Tsr proteins is maximal under optimal temperature. The data further suggests that the weakening of the clustering process in lower-than and higher-than optimal temperatures is not due to the same cause. Meanwhile, the location of the clusters is found to be weakly temperature independent, within the range tested. We conclude that while the clustering of Tsr is heavily temperature dependent, the localization is only weakly dependent, suggesting that the functionality of the proteins responsible for retaining Tsr-clusters at the cell poles, such as the Tol-Pal complex, is robust to suboptimal temperatures.

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Paper citation in several formats:
Annila, T.; Neeli-Venkata, R. and Ribeiro, A. (2016). Robustness to Sub-optimal Temperatures of the Processes of Tsr Cluster Formation and Positioning in Escherichia Coli. In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS; ISBN 978-989-758-170-0; ISSN 2184-4305, SciTePress, pages 137-141. DOI: 10.5220/0005647001370141

@conference{bioinformatics16,
author={Teppo Annila. and Ramakanth Neeli{-}Venkata. and Andre S. Ribeiro.},
title={Robustness to Sub-optimal Temperatures of the Processes of Tsr Cluster Formation and Positioning in Escherichia Coli},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS},
year={2016},
pages={137-141},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005647001370141},
isbn={978-989-758-170-0},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOINFORMATICS
TI - Robustness to Sub-optimal Temperatures of the Processes of Tsr Cluster Formation and Positioning in Escherichia Coli
SN - 978-989-758-170-0
IS - 2184-4305
AU - Annila, T.
AU - Neeli-Venkata, R.
AU - Ribeiro, A.
PY - 2016
SP - 137
EP - 141
DO - 10.5220/0005647001370141
PB - SciTePress

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