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Authors: Norhayati Ahmat 1 ; Gabriela González Castro 2 and Hassan Ugail 2

Affiliations: 1 University of Bradford, Faculty of Science and Mathematics and Universiti Pendidikan Sultan Idris, United Kingdom ; 2 University of Bradford, United Kingdom

Keyword(s): Pde Method, Parametric Surfaces, Pharmaceutical Tablets, Automatic Optimisation.

Related Ontology Subjects/Areas/Topics: Formal Methods ; Mathematical Simulation ; Optimization Issues ; Simulation and Modeling ; Simulation Tools and Platforms ; Virtual Reality and Graphical Simulations

Abstract: Pharmaceutical tablets and capsules are the dominant forms for drug delivery. Both types of dosage forms need to be strong enough to handle different types of stress due to packaging and loading conditions before use. Hence, it is important to produce these pharmaceutical forms with maximum mechanical strength while conserving the properties of their active ingredients during the design process. The present work describes a methodology for parametric design and optimisation of a solid cylindrical tablet and a soft spherical capsule, which is based on the use of Partial Differential Equations (PDEs). The PDE-based formulation is capable of parameterising complex shapes using the information at some boundary curves that describe the shape. It is shown that the optimal designs of both tablet and capsule can be obtained using an automatic design optimisation which is performed by combining the PDE method and a standard method for numerical optimisation.

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Paper citation in several formats:
Ahmat, N.; González Castro, G. and Ugail, H. (2012). Automatic Design Optimisation of Pharmaceutical Tablets using PDEs. In Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH; ISBN 978-989-8565-20-4; ISSN 2184-2841, SciTePress, pages 125-130. DOI: 10.5220/0004059601250130

@conference{simultech12,
author={Norhayati Ahmat. and Gabriela {González Castro}. and Hassan Ugail.},
title={Automatic Design Optimisation of Pharmaceutical Tablets using PDEs},
booktitle={Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH},
year={2012},
pages={125-130},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004059601250130},
isbn={978-989-8565-20-4},
issn={2184-2841},
}

TY - CONF

JO - Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH
TI - Automatic Design Optimisation of Pharmaceutical Tablets using PDEs
SN - 978-989-8565-20-4
IS - 2184-2841
AU - Ahmat, N.
AU - González Castro, G.
AU - Ugail, H.
PY - 2012
SP - 125
EP - 130
DO - 10.5220/0004059601250130
PB - SciTePress

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