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Authors: Aura Silva 1 ; Almir P. Souza 2 ; Carlos Venâncio 1 ; David A. Ferreira 1 and Luis Antunes 1

Affiliations: 1 Universidade de Trás-os-Montes e Alto Douro, Portugal ; 2 Universidade Federal de Campina Grande, Brazil

Keyword(s): Anesthesia, electroencephalogram, dexmedetomidine, ketamine, index of consciousness, permutation entropy

Abstract: The Index of Consciousness (IoC) and the Permutation Entropy (PE) are the most recent EEG-based indexes for depth of anesthesia monitoring but their use during ketamine or dexmedetomidine anesthesia has never been reported. In this study, the ability of these measures o differentiate between the effects of two different doses of dexmedetomidine combined with a fixed dose of ketamine in rabbits was studied. Five adult female rabbits received one of two ketamine/dexmedetomidine com-binations (15/0.025 and 15/0.05 mg/kg: G0.025 and G0.05, respectively). The effect of the two doses on IoC and PE were compared. The effect of dexmedetomidine dosage on the EEG was not significantly different between groups for any of the studied indexes (IoC (p=0.058); PE (p=0.392)). Only the IoC showed a significantly lower value in G0.05 than G0.025 at T15. The analysis revealed a significant effect of time on the IoC (p=0.001) and PE (p=0.0195). IoC and PE did not decrease to values correspondent to t he anesthetized state, as was expected regarding previous works. This may be explained by the known excitatory effects of ketamine on the EEG. However, the tendency of the indexes to decrease after induction and to be lower in the animals that received the higher dexmedetomidine dosage suggests the capacity of these parameters to detect depressant effects of alpha-2-agonists. (More)

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Paper citation in several formats:
Silva, A.; P. Souza, A.; Venâncio, C.; A. Ferreira, D. and Antunes, L. (2012). Effect of Two Doses of Dexmedetomidine on Index of Consciousness and Permutation Entropy in Rabbits. In Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB; ISBN 978-989-8425-94-2, SciTePress, pages 43-50. DOI: 10.5220/0003879100430050

@conference{vbb12,
author={Aura Silva. and Almir {P. Souza}. and Carlos Venâncio. and David {A. Ferreira}. and Luis Antunes.},
title={Effect of Two Doses of Dexmedetomidine on Index of Consciousness and Permutation Entropy in Rabbits},
booktitle={Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB},
year={2012},
pages={43-50},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003879100430050},
isbn={978-989-8425-94-2},
}

TY - CONF

JO - Proceedings of the International Workshop on Veterinary Biosignals and Biodevices (BIOSTEC 2012) - VBB
TI - Effect of Two Doses of Dexmedetomidine on Index of Consciousness and Permutation Entropy in Rabbits
SN - 978-989-8425-94-2
AU - Silva, A.
AU - P. Souza, A.
AU - Venâncio, C.
AU - A. Ferreira, D.
AU - Antunes, L.
PY - 2012
SP - 43
EP - 50
DO - 10.5220/0003879100430050
PB - SciTePress

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