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Authors: Mohammad Ali Moni 1 ; Pietro Liò 1 and Luciano Milanesi 2

Affiliations: 1 Cambridge University, United Kingdom ; 2 Institute for Biomedical Technologies, Italy

Keyword(s): Osteomyelitis, HIV, Staphylococcus aureus.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Computational Molecular Systems ; Databases and Data Management ; Model Design and Evaluation ; Structural Bioinformatics ; Systems Biology

Abstract: This paper focuses on the differences between S. aureus bacterial and HIV viral infection of the bone tissue. Both of these infections alters the RANK/RANKL/OPG signalling dynamics that regulates osteoblasts and osteoclasts behavior in bone remodelling. These infections rapidly lead to severe bone loss and it may even spread to other parts of the body. Since both HIV and osteomyelitis cause loss of bone mass, we focused on comparing the dynamics of these diseases by means of computational models. Firstly, we performed meta-analysis on the gene expression data of normal, HIV and osteomyelitis bone conditions and compare the effects of HIV and S. aureus infection. We mainly focused on RANKL/OPG signalling, the TNF and TNF receptor superfamilies and the NF-kB pathway. Using information from the gene expression data, we estimated parameters for a novel model of osteomyelitis. Then we develop another multi strain HIV ODE model incorporating the HAART therapy. Our ODE modelling aims at inv estigating the dynamics of the effects of osteomyelitis and HIV infection in bone remodelling. (More)

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Paper citation in several formats:
Ali Moni, M.; Liò, P. and Milanesi, L. (2013). Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS; ISBN 978-989-8565-35-8; ISSN 2184-4305, SciTePress, pages 196-201. DOI: 10.5220/0004249801960201

@conference{bioinformatics13,
author={Mohammad {Ali Moni}. and Pietro Liò. and Luciano Milanesi.},
title={Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS},
year={2013},
pages={196-201},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004249801960201},
isbn={978-989-8565-35-8},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2013) - BIOINFORMATICS
TI - Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue
SN - 978-989-8565-35-8
IS - 2184-4305
AU - Ali Moni, M.
AU - Liò, P.
AU - Milanesi, L.
PY - 2013
SP - 196
EP - 201
DO - 10.5220/0004249801960201
PB - SciTePress

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