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Authors: Febry Rahmadhani Hasibuan 1 ; It Jamilah 2 and Sovia Lenny 2

Affiliations: 1 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia ; 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia

Keyword(s): Allium chinense G. Don., Prodigiosin, Serratia marcescens

Abstract: Bawang Batak (Allium chinense G. Don.) is one of native medicinal plants utilized as spices in North Sumatera, Indonesia. The plant is known to exhibit antimicrobial activities against several bacterial pathogens. Prospect of finding a new mechanism in combating bacterial infection through quorum-sensing inhibition is an alternative way yet promising strategy to the overuse of antibiotics. The aim of this study is to obtain the optimum concentration of methanolic (MeOH) and ethyl acetate (EtOAc) extracts of A. chinense as quorum-sensing inhibitors to prodigiosin synthesis by S. marcescens. The inhibition of prodigiosin synthesis is observed visually and measured in absorbance value (A534) compared to control. The results showed that both extracts did not inhibit the growth of tested strain based on optical density (OD600) among tested concentrations. The higher the concentration of MeOH and EtOAc extracts, the less synthesis of prodigiosin by S. marcescens in the concentration of 0. 3% (w/v) at the end of incubation period (30h). The results showed that MeOH and EtOAc extract may be studied thoroughly for its possibility as quorum-sensing inhibitor following further parameters in the future. (More)

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Paper citation in several formats:
Hasibuan, F.; Jamilah, I. and Lenny, S. (2019). Inhibitory Activity of Allium chinense G. Don. Extracts to Prodigiosin Synthesis by Serratia Marcescens. In Proceedings of the International Conference on Natural Resources and Technology - ICONART; ISBN 978-989-758-404-6, SciTePress, pages 82-86. DOI: 10.5220/0008506200820086

@conference{iconart19,
author={Febry Rahmadhani Hasibuan. and It Jamilah. and Sovia Lenny.},
title={Inhibitory Activity of Allium chinense G. Don. Extracts to Prodigiosin Synthesis by Serratia Marcescens},
booktitle={Proceedings of the International Conference on Natural Resources and Technology - ICONART},
year={2019},
pages={82-86},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008506200820086},
isbn={978-989-758-404-6},
}

TY - CONF

JO - Proceedings of the International Conference on Natural Resources and Technology - ICONART
TI - Inhibitory Activity of Allium chinense G. Don. Extracts to Prodigiosin Synthesis by Serratia Marcescens
SN - 978-989-758-404-6
AU - Hasibuan, F.
AU - Jamilah, I.
AU - Lenny, S.
PY - 2019
SP - 82
EP - 86
DO - 10.5220/0008506200820086
PB - SciTePress

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