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Authors: Alžbeta Bohiniková 1 ; Inês Maia 2 ; 3 ; Monika Smiešková 1 ; Alžbeta Bugáňová 1 ; Ana S. Moita 2 ; Ivan Cimrák 1 and Rui A. A. Lima 3 ; 4

Affiliations: 1 Cell-in-fluid: Biomedical Modeling and Computation Group, University of Zilina, Slovakia ; 2 IN+ Center for Innovation, Technology and Policy Research, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal ; 3 Metrics, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal ; 4 CEFT, Faculdade de Engenharia da Universidade do Porto (FEUP), R. Dr. Roberto Frias, 4200-465 Porto, Portugal

Keyword(s): Computational Cell Model, Microfluidic Devices, Cell Deformation.

Abstract: This article describes the overview of the steps required to derive and validate a new model on cell behaviour in microfluidic devices, from the experimental approach to the computational model. The paper identifies the challenges of the biological side of the experiments and shows where computational power can be useful. It also emphasizes the necessity for the collaboration between the experimental and computational research groups. Computations can offer great insides into the mechanics of cells, however, interesting applications mainly arise from combining nunerics with experiments. Well calibrated and verified model can be used to improve the performance of a given microfluidic device by testing various geometries and thus lowering the number of devices that need to be produced. Choosing several designs of microfluidic devices one tries to demonstrate the wide range of possible uses of the microfluidic technology and how the computations can enrich them.

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Paper citation in several formats:
Bohiniková, A. ; Maia, I. ; Smiešková, M. ; Bugáňová, A. ; Moita, A. ; Cimrák, I. and A. Lima, R. (2020). Assessment of Computational Cell Model Benefits for Optimization of Microfluidic Devices. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIODEVICES; ISBN 978-989-758-398-8; ISSN 2184-4305, SciTePress, pages 280-287. DOI: 10.5220/0009173202800287

@conference{biodevices20,
author={Alžbeta Bohiniková and Inês Maia and Monika Smiešková and Alžbeta Bugáňová and Ana S. Moita and Ivan Cimrák and Rui A. {A. Lima}},
title={Assessment of Computational Cell Model Benefits for Optimization of Microfluidic Devices},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIODEVICES},
year={2020},
pages={280-287},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009173202800287},
isbn={978-989-758-398-8},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIODEVICES
TI - Assessment of Computational Cell Model Benefits for Optimization of Microfluidic Devices
SN - 978-989-758-398-8
IS - 2184-4305
AU - Bohiniková, A.
AU - Maia, I.
AU - Smiešková, M.
AU - Bugáňová, A.
AU - Moita, A.
AU - Cimrák, I.
AU - A. Lima, R.
PY - 2020
SP - 280
EP - 287
DO - 10.5220/0009173202800287
PB - SciTePress

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