Authors:
J. van Leeuwen
1
;
A. Bucur
1
;
B. Claerhout
2
;
K. De Schepper
2
;
D. Perez-Rey
3
and
R. Alonso-Calvo
3
Affiliations:
1
Philips Electronics BV, Netherlands
;
2
Custodix NV, Belgium
;
3
Universidad Politécnica de Madrid, Spain
Keyword(s):
Clinical Trials, Trial Metadata, Trial Metadata Repository, Semantic Interoperability, Trial Eligibility.
Related
Ontology
Subjects/Areas/Topics:
Artificial Intelligence
;
Biomedical Engineering
;
Collaboration and e-Services
;
Complex Systems Modeling and Simulation
;
Data Engineering
;
Decision Support Systems
;
e-Business
;
Enterprise Information Systems
;
Health Information Systems
;
Healthcare Management Systems
;
Information Systems Analysis and Specification
;
Integration/Interoperability
;
Interoperability
;
Knowledge Management
;
Knowledge Management and Information Sharing
;
Knowledge-Based Systems
;
Ontologies and the Semantic Web
;
Semantic Interoperability
;
Sensor Networks
;
Simulation and Modeling
;
Society, e-Business and e-Government
;
Software Agents and Internet Computing
;
Software and Architectures
;
Symbolic Systems
;
Web Information Systems and Technologies
Abstract:
Making information about clinical trials accessible in a machine interpretable way could aid applications both in clinical care and clinical research, such as patient screening, trial recruitment, trial meta-analysis, trial duplication detection and clinical decision support. We present our standards-based trial metadata repository that captures structured trial information and application-specific formalisms and execution logic supporting a range of relevant applications, with a focus on interoperability and machine interpretability to enable more efficient support for clinical research and faster knowledge transfer into care, We further exemplify the use of the Trial Metadata Repository for a patient screening application for clinical trials. Additionally, the mechanisms are described to manage the information model of the repository when the scope is enlarged to additional contexts.