Authors:
Akhmad Mubarok
1
;
Heny Arwati
2
and
Yoes Prijatna Dahlan
2
Affiliations:
1
Department of Immunology Postgraduate School, Universitas Airlangga, Airlangga Street 4-6, Surabaya and Indonesia, Indonesia
;
2
Department of Parasitology Faculty of Medicine, Universitas Airlangga, Surabaya and Indonesia, Indonesia
Keyword(s):
parasite density, Plasmodium falciparum, TNF-α, IL-10
Abstract:
Introduction: Malaria is caused by female mosquito anopheles bite transmitting malaria parasite sporozoite stage into the human body. Data Word Health Organization shows case causing malaria death to reach 429.000, this need commitment of every country to overcome malaria. Indonesia is still a malaria endemic
area and includes a country with a high risk of malaria. Population migration from malaria endemic areas to non-endemic areas of malaria is responsible for malaria transmission, especially in Papua, West Papua, Maluku, North Maluku and East Nusa Tenggara. Malaria case in East Nusa Tenggara Province 7,05% per
1000 population based on annual parasite icidence (API) and 36,039 positive. East Sumba 12,84% per 1000 population. Methods: A descriptive cross sectional study was conducted in East Sumba district using the Logical Framework approach. Twenty two people were involved in this study with ranging age 4 to 50 years.
The presence of density parasit be examined using microscope, c
ytokine TNF-α and Interleukin-10 analyzed using enzyme linked immunosorbent assay (ELISA) Result: Significant values considered at p<0,05. The result show that parasite density 7.72 ± 9.51 /μl. TNF-α 27.14 ± 50.22 pg/ml IL-10 2.20 ± 3.23 pg/ml
Conclusion: The result from this study conclude parasite density increases of TNF-α and IL-10 cytokine.
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