Parallel and Distributed Agent-based Simulation of Large-scale Socio-technical Systems with Loosely Coupled Virtual Machines Topics: Agent-Directed Simulation; Biological and Social Systems Simulation; Computer Simulation Techniques; Cyber-Physical-Social Systems; Distributed and Parallel Simulation; Environmental Modeling; Healthcare and Elderly Care; Industrial Processes; Intelligent Transportation; Internet of Things (IoT) Systems; Laboratory Simulation Software; Performance Analysis; Simulation of Energy Systems In Proceedings of the 11th International Conference on Simulation and Modeling Methodologies, Technologies and Applications SIMULTECH - Volume 1, 344-351, 2021