Authors:
Mikhail Makmatov-Rys
1
;
Alexey Glazkov
1
;
Irina Raznitsyna
1
;
Dmitriy Kulikov
1
;
2
;
Anton Molochkov
1
;
Albina Khlebnikova
1
;
Ekaterina Kaznacheeva
3
;
Alexey Sekirin
1
and
Dmitry Rogatkin
1
Affiliations:
1
Moscow Regional Research and Clinical Institute "MONIKI", 61/2, Shchepkina Str., Moscow, RF, 129110, Russian Federation
;
2
Institute of Public Health named after N.A. Semashko, 12/1c1 Vorontsovo Pole Str., Moscow, RF, 105064, Russian Federation
;
3
Cosmetological Clinic «Lemark», Voronezh, 32 Vladimir Nevsky Str., RF, 394088, Russian Federation
Keyword(s):
Ultraviolet Erythema, Minimal Erythema Dose, Inflammation, Fluorescence, Saturation, Non-invasive, Diagnostics.
Abstract:
Currently, in clinical practice, the assessment of ultraviolet (UV) -induced erythema and the determination of the minimal erythema dose (MED) is done visually, which is subjective, inaccurate and associated with high variability of the results. To solve this problem, the application of optical methods seems promising, allowing us to evaluate changes in epidermis and dermis induced by UV exposure. In this study the analysis of endogenous fluorescence and microcirculation characteristics by non-invasive optical methods revealed the relationship between the intensity of endogenous fluorescence of porphyrins and oxygen consumption with a dose of UV radiation. The correlation of the intensity of endogenous fluorescence of the irradiated region normalized to intact tissue with a dose of UV was demonstrated. Therefore, optical diagnostic methods can be a promising tool for non-invasive and quantitative assessment of UV erythema and MED.