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Authors: Helena Aidos ; João Duarte and Ana Fred

Affiliation: Instituto Superior Técnico, Portugal

Keyword(s): Support Vector Machines, ROI, Feature Extraction, Image Segmentation, Mutual Information.

Related Ontology Subjects/Areas/Topics: Bioimaging ; Biomedical Engineering ; Brain Function Analysis ; Cardiovascular Imaging and Cardiography ; Cardiovascular Technologies ; Health Engineering and Technology Applications ; Medical Imaging and Diagnosis ; Positron Emission Tomography (PET)

Abstract: Alzheimer's disease is a type of dementia that mainly affects elderly people, with unknown causes and no effective treatment up to date. The diagnosis of this disease in an earlier stage is crucial to improve patients' life quality. Current techniques focus on the analysis of neuroimages, like FDG-PET or MRI, to find changes in the brain activity. While high accuracies can be obtained by combining the analysis of several types of neuroimages, they are expensive and not always available for medical analysis. Achieving similar results using only 3-D FDG-PET scans is therefore of huge importance. While directly applying classifiers to the FDG-PET scan voxel intensities can lead to good prediction accuracies, it results in a problem that suffers from the curse of dimensionality. This paper thus proposes a methodology to identify regions of interest by segmenting 3-D FDG-PET scans and extracting features that represent each of those regions of interest, reducing the dimensionality of the space. Experimental results show that the proposed methodology outperforms the one using voxel intensities despite only a small number of features is needed to achieve that result. (More)

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Paper citation in several formats:
Aidos, H.; Duarte, J. and Fred, A. (2014). Finding Coherent Regions in PET Images for the Diagnosis of Alzheimer’s Disease. In Proceedings of the International Conference on Bioimaging (BIOSTEC 2014) - BIOIMAGING; ISBN 978-989-758-014-7; ISSN 2184-4305, SciTePress, pages 12-18. DOI: 10.5220/0004802200120018

@conference{bioimaging14,
author={Helena Aidos. and João Duarte. and Ana Fred.},
title={Finding Coherent Regions in PET Images for the Diagnosis of Alzheimer’s Disease},
booktitle={Proceedings of the International Conference on Bioimaging (BIOSTEC 2014) - BIOIMAGING},
year={2014},
pages={12-18},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004802200120018},
isbn={978-989-758-014-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioimaging (BIOSTEC 2014) - BIOIMAGING
TI - Finding Coherent Regions in PET Images for the Diagnosis of Alzheimer’s Disease
SN - 978-989-758-014-7
IS - 2184-4305
AU - Aidos, H.
AU - Duarte, J.
AU - Fred, A.
PY - 2014
SP - 12
EP - 18
DO - 10.5220/0004802200120018
PB - SciTePress