Authors:
V. F. Cardoso
;
J. G. Rocha
;
F. O. Soares
;
G. Minas
and
S. Lanceros-Mendez
Affiliation:
University of Minho, Portugal
Keyword(s):
Lab-on-a-chip, PVDF, acoustic microagitation, SU-8.
Related
Ontology
Subjects/Areas/Topics:
Biocomputing and Biochips
;
Biomedical Engineering
;
Biomedical Instruments and Devices
;
Devices
;
Health Monitoring Devices
;
Human-Computer Interaction
;
Physiological Computing Systems
Abstract:
The main objective of this article is to describe the development of a fully-integrated disposable lab-on-a-chip for point of care testing and monitoring of biochemical parameters in biological fluids. The lab-on-a-chip is composed mainly by two dies: the fluid and the detection. The fluid die, fabricated in SU-8, comprises three microfluidic cuvettes, containing the fluids into analysis, and a β-PVDF microagitation system. The detection die is fabricated in a CMOS standard process and contains the photodetectors and the electronics for signal actuation and detection. The main innovation of this lab-on-a-chip is the application of an acoustic microagitation technique by the deposition of the β-PVDF piezoelectric polymer underneath the microfluidic structures, with automatic electronic control. This piezoelectric polymer produces mechanical vibrations, which allow the enhancement of the mixing and the reaction.