TWO-STAGE CLUSTERING OF A HUMAN BRAIN TUMOUR DATASET USING MANIFOLD LEARNING MODELS

Raúl Cruz-Barbosa, Alfredo Vellido

2008

Abstract

This paper analyzes, through clustering and visualization, Magnetic Resonance spectra of a complex multi-center human brain tumour dataset. Clustering is performed as a two-stage process, in which the models used in the first stage are variants of Generative Topographic Mapping (GTM). Class information-enriched variants of GTM are used to obtain a primary cluster description of the data. The number of clusters used by GTM is usually large and does not necessarily correspond to the overall class structure. Consequently, in a second stage, clusters are agglomerated using K-means with different initialization strategies, some of them defined ad hoc for the GTM models. We evaluate if the use of class information influence the brain tumour cluster-wise class separability resulting from the process. We also resort to a robust variant of GTM that detects outliers while effectively minimizing their negative impact in the clustering process.

Paper Citation

in Harvard Style

Cruz-Barbosa R. and Vellido A. (2008). TWO-STAGE CLUSTERING OF A HUMAN BRAIN TUMOUR DATASET USING MANIFOLD LEARNING MODELS . In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008) ISBN 978-989-8111-18-0, pages 191-196. DOI: 10.5220/0001058501910196

in Bibtex Style

@conference{biosignals08,
author={Raúl Cruz-Barbosa and Alfredo Vellido},
title={TWO-STAGE CLUSTERING OF A HUMAN BRAIN TUMOUR DATASET USING MANIFOLD LEARNING MODELS},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)},
year={2008},
pages={191-196},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001058501910196},
isbn={978-989-8111-18-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)
TI - TWO-STAGE CLUSTERING OF A HUMAN BRAIN TUMOUR DATASET USING MANIFOLD LEARNING MODELS
SN - 978-989-8111-18-0
AU - Cruz-Barbosa R.
AU - Vellido A.
PY - 2008
SP - 191
EP - 196
DO - 10.5220/0001058501910196