A SECURE WEB APPLICATION PROVIDING PUBLIC ACCESS TO HIGH-PERFORMANCE DATA INTENSIVE SCIENTIFIC RESOURCES - ScalaBLAST Web Application

Darren Curtis, Elena Peterson, Christopher Oehmen

2008

Abstract

This work presents the ScalaBLAST Web Application (SWA), a web based application implemented using the PHP script language, MySQL DBMS, and Apache web server under a GNU/Linux platform. SWA is an application built as part of the Data Intensive Computer for Complex Biological Systems (DICCBS) project at the Pacific Northwest National Laboratory (PNNL). SWA delivers accelerated throughput of bioinformatics analysis via high-performance computing through a convenient, easy-to-use web interface. This approach greatly enhances emerging fields of study in biology such as ontology-based homology, and multiple whole genome comparisons which, in the absence of a tool like SWA, require a heroic effort to overcome the computational bottleneck associated with genome analysis. The current version of SWA includes a user account management system, a web based user interface, and a backend process that generates the files necessary for the Internet scientific community to submit a ScalaBLAST parallel processing job on a dedicated cluster.

References

  1. Altschul, S., Gish, W., Miller, W., Myers, E. & Lipman, D. (1990). “Basic Local Alignment Search Tool”, J. Molecular Biology. 215, p403-410.
  2. Altschul, S., Madden, T., Schaffer, A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. (1997). “Gapped BLAST and PSI-BLAST”, Nucleic Acids Research. 25, p3389- 3402.
  3. Cannon, W., Jarman, K.H., Webb-Robertson, B., Baxter, D., Oehmen, C., Jarman, K.D., Heredia-Langner, A, Auberry, K., Anderson, G. (2005). Comparison of Probability and Likelihood Models for Peptide Identification From Tandem Mass Spectrometry Data. J. Proteome Res. 4(5), p1687-98.
  4. Harvard. (2007). BatchBLAST: A Java Software With Graphical User Interface To Blast Multiple Sequences Against Multiple Databases In Batch Mode [online]. Available: http://www.hip.harvard.edu/informatics/programs/JA VA%20BLAST%20Parser.html [Accessed 15 October 2007].
  5. NCBI - National Center for Biotechnology Information. (2007). BLAST: Basic Local Alignment and Search Tool [online]. Available: http://www.ncbi.nlm.nih.gov/BLAST [Accessed 23 August 2007].
  6. NuSphere. (2007). PHP IDE - Integrated Development Environment for PHP [online]. Available: http://www.nusphere.com/products/phped.htm [Accessed 15 October 2007].
  7. Oehmen, Christopher & Nieplocha, Jarek. (2006). "ScalaBLAST: A Scalable Implementation of BLAST for High-Performance Data-Intensive Bioinformatics Analysis". IEEE Transactions on Parallel and Distributed Systems. 17 (8), p740-749.
  8. OpenPBS. (2007). OpenPBS: Portable Batch System [online]. Available: http://www.openpbs.org/ [Accessed 15 October 2007].
  9. OpenQA. (2007). OpenQA: Selenium [online]. Available: http://www.openqa.org/selenium [Accessed 15 October 2007].
  10. Raz, Uri. (2007). How do spammers harvest email addresses? [online]. Available: http://www.private.org.il/harvest.html [Accessed 15 October 2007].
  11. Source Viewer. (2007). Source Viewer [online]. Available: http://source-viewer.softswot.qarchive.org [Accessed 15 October 2007].
  12. VanDyk, John K. & Westgate, Matt. (2007). Pro Drupal Development. New York: Apress. p1-10.
  13. Washington University in St. Louis, Genome Sequencing Center. (2007). GSC: BLAST Server [online]. Available: http://genome.wustl.edu/tools/blast [Accessed 15 October 2007].
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Paper Citation


in Harvard Style

Curtis D., Peterson E. and Oehmen C. (2008). A SECURE WEB APPLICATION PROVIDING PUBLIC ACCESS TO HIGH-PERFORMANCE DATA INTENSIVE SCIENTIFIC RESOURCES - ScalaBLAST Web Application . In Proceedings of the Fourth International Conference on Web Information Systems and Technologies - Volume 1: WEBIST, ISBN 978-989-8111-26-5, pages 244-251. DOI: 10.5220/0001521902440251


in Bibtex Style

@conference{webist08,
author={Darren Curtis and Elena Peterson and Christopher Oehmen},
title={A SECURE WEB APPLICATION PROVIDING PUBLIC ACCESS TO HIGH-PERFORMANCE DATA INTENSIVE SCIENTIFIC RESOURCES - ScalaBLAST Web Application},
booktitle={Proceedings of the Fourth International Conference on Web Information Systems and Technologies - Volume 1: WEBIST,},
year={2008},
pages={244-251},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001521902440251},
isbn={978-989-8111-26-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Fourth International Conference on Web Information Systems and Technologies - Volume 1: WEBIST,
TI - A SECURE WEB APPLICATION PROVIDING PUBLIC ACCESS TO HIGH-PERFORMANCE DATA INTENSIVE SCIENTIFIC RESOURCES - ScalaBLAST Web Application
SN - 978-989-8111-26-5
AU - Curtis D.
AU - Peterson E.
AU - Oehmen C.
PY - 2008
SP - 244
EP - 251
DO - 10.5220/0001521902440251