CEREBRAL CORRELATES OF THE CONTINOUS PERFORMANCE TEST-IDENTICAL PAIRS VERSION - An fMRI Study

J. M. Serra-Grabulosa, A. Adan, C. Falcón, N. Bargalló, J. Solé-Casals

2010

Abstract

One of the most used paradigms in the study of the attention is the Continuous Performance Test (CPT). The Identical Pairs version of the CPT (CPT-IP) has been used to evaluate attention deficits in developmental, neurological and psychiatric disorders. Since both dyscalculia and ADHD (attention deficit hyperactivity disorder) show attentional and numerical processing deficits, it would be interesting to evaluate functional brain patterns related to the CPT-IP in a task which uses numerical stimuli. In this sense, the aim of our study was to design a task to evaluate sustained attention using functional magnetic resonance imaging. This task has to be sensitive to evaluate later dyscalculic and ADHD subjects. Forty right-handed, healthy subjects (20 women; age range 18–25) were recruited to participate in the study. A CPT-IP implemented as a block design was used to assess sustained attention in the fMRI session. Results showed the CPT-IP task used activates a network of frontal, parietal and occipital areas and could be related to executive, attentional and numerical processing functions.

References

  1. Barkley, R. A., 2003. Issues in the diagnosis of attentiondeficit/hyperactivity disorder in children. Brain and Development, 25, 7-83.
  2. Carlson, T., Grol, M.J., Verstraten, F.A., 2006. Dynamics of visual recognition revealed by fMRI. Neuroimage, 32 (2), 892-905.
  3. Casey, B.J., Formans, S.D., Franzen, P., Berkowitz, A., Braver, T.S., Nystrom, L.E. et al., 2001. Sensitivity of prefrontal cortex to changes in target probability: a functional MRI study. Human Brain Mapping, 13 (1), 26-33.
  4. Cornblatt, B.A., Lezenweger, M.F., Erlenmeyer-Kimling, L., 1989. The Continuous Performance Test, Identical Pairs Version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Research, 29, 65-85.
  5. Coull, J.T., Frith, C.D., Frackowiak, R.S.J., Grasby, P.M., 1996. A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia, 34, 1085-95.
  6. D'Esposito, M. Working memory. (2008). En Handbook of Clinical Neurology, Neuropsychology and behavioral neurolgoy. G. Goldenberg i B. Miller (Eds.).
  7. Dehaene, S., Molko, N., Cohen, L., Wilson, A.J., 2004. Arithmetic and the brain. Current Opinion in Neurobiology, 14 (2), 218-24.
  8. Fan, J., McCandliss, B. D., Fossella, J., Flombaum, J. I., Posner, M. I., 2005. The activation of attentional networks. Neuroimage, 26, 471-9.
  9. Grill-Spector, K., Kourtzi, Z., Kanwisher, N., 2001. The lateral occipital complex and its role in object recognition.Vision Research, 41(10-11), 1409-22.
  10. Grodzinsky, Y., Santi, A., 2008. The battle for Broca's region. Trends in Cognitive Sciences 12 (12), 474-80.
  11. Gusnard, D.A., Raichle, M.E., 2001. Searching for a baseline: Functional imaging and the resting human brain. Nature Neuroscience Reviews, 2, 685-94.
  12. Hill, D.E., Yeo, R.A., Campbell, R.A., Hart, B., Vigil, J, Brooks, W., 2003. Magnetic ressonance imaging correlates of Attention-Deficit/Hyperactivity Disorder in children. Neuropsychology, 17 (3), 496-506.
  13. Jonides, J.,Schumacher, E.H., Smith, E.E., Koeppe, R.A., Awh, E., Reuter-Lorentz, P.A., Marshuetz, C., Willis, C.R., 1998. The role of parietal cortex in verbal working memory. Journal of Neuroscience, 18, 5026- 34.
  14. Kelton, M.C., Kahn, H.J., Conrath, C.L., Newhouse, P., 2000. The effects of nicotine on Parkinson's disease. Brain and Cognition, 43, 274-82.
  15. Konrad, K., Neufang, S., Thiel, C.M., Specht, K., Hanisch, C., Fan, J., Herpertz-Dahlmann, B., Fink, G.R., 2005. Development of attentional networks: an fMRI study with children and adults. Neuroimage 28 (2), 429-39.
  16. Lawrence, N.S., Ross, T.J., Hoffman, R., Garavan, H., Stein, E.A., 2003. Multiple neuronal networks mediate sustained attention. Journal of Cognitive Neuroscience, 15 (7), 1028-38.
  17. Lindsay, R.L., Tomazic, T., Levine, M.D., Accardo, P.J., 2001. Attentional function as measured by a continuos performance task in children with dyscalculia. Journal of Developmental and and Behavioral Pediatrics, 42 (8), 1049-56.
  18. McKiernan, K.A., Kaufman, J.N., Kucera-Thompson, J., Binder, J.R., 2003. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. Journal of Cognitive Neuroscience, 15, 394-408.
  19. Ogg, R.J., Zou, P., Allen, D.N., Hutchins, S.B., Dutkiewicz, R.M., Mulhern, R.K., 2008. Neural correlates of a clinical continuous performance test. Magnetic Resonance Imaging, 26, 504-12.
  20. Pardo, J.V., Fox, P.T., Raichle, M.E., 1991. Localization of a human system for sustained attention by positron emission tomography. Nature, 349, 61-4.
  21. Passolunghi, M.C., Siegel, L.S., 2001. Short-term memory, working memory, and inhibitory control in children with difficulties in arithmetic problem solving. Journal of Experimental Child Psychology, 80, 44-57.
  22. Posner, M. I., DiGirolamo, G. J., 2000. Attention in cognitive neuroscience: An overview. A Gazzaniga, M. S. (Comp). The new cognitive neurosciences (pp 623-31). Cambridge: MIT Press.
  23. Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., 2001. A default mode of brain function. Proceedings of the National Academy of Sciences, 98, 676-82.
  24. Raz, A., Buhle, J., 2006. Typologies of attentional networks. Nature Reviews Neuroscience, 7 (5), 367- 79.
  25. Ridderinkhof, K.R., Ullsperger, M., Crone, E.A. Nieuwenhuis, S., 2004. The role of the medial frontal cortex in cognitive control. Science, 306, 443-7.
  26. Rubinsten, O., Henik, A., 2009. Developmental dyscalculia: heterogeneity might not mean different mechanisms. Trends in Cognitive Sciences, 13 (2), 99- 9.
  27. Schmithorst, V.J., Brown, R.D., 2004. Empirical validation of the triple-code model of numerical processing for complex math operations using functional MRI and group Independent Component Analysis of the mental addition and subtraction of fractions. Neuroimage, 22 (3), 1414-20.
  28. Shalev, R.S., Auerbach, J., Gross-Tsur, V., 1995. Developmental dyscalculia behavioral and attentional aspects: A research note. Journal of Child Psychology and Psychiatry, 36, 1261-68.
  29. Strakowski, S.M., Adler, C.M., Holland, S.K., Mills, N., DelBello, M.P., 2004. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology, 29 (9), 1734-40.
  30. Vinckier, F., Dehaene, S., Jobert, A., Dubus, J.P., Sigman, M., Cohen, L., 2007. Hierarchical coding of letter strings in the ventral stream: dissecting the inner organization of the visual word-form system. Neuron 55 (1), 143-56.
  31. White, H.K., Levin, E.D., 1999. Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. Psyichopharmacology, 143, 58- 165.
  32. Zago, L., Petit, L., Turbelin, M.R., Andersson, F., Vigneau, M., Tzourio-Mazoyer, N., 2008. How verbal and spatial manipulation networks contribute to calculation: an fMRI study. Neuropsychologia, 46 (9), 2403-14.
Download


Paper Citation


in Harvard Style

M. Serra-Grabulosa J., Adan A., Falcón C., Bargalló N. and Solé-Casals J. (2010). CEREBRAL CORRELATES OF THE CONTINOUS PERFORMANCE TEST-IDENTICAL PAIRS VERSION - An fMRI Study . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: Special Session on Neural Signals of Brain Disorde, (BIOSTEC 2010) ISBN 978-989-674-018-4, pages 491-496. DOI: 10.5220/0002758604910496


in Bibtex Style

@conference{special session on neural signals of brain disorde10,
author={J. M. Serra-Grabulosa and A. Adan and C. Falcón and N. Bargalló and J. Solé-Casals},
title={CEREBRAL CORRELATES OF THE CONTINOUS PERFORMANCE TEST-IDENTICAL PAIRS VERSION - An fMRI Study},
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: Special Session on Neural Signals of Brain Disorde, (BIOSTEC 2010)},
year={2010},
pages={491-496},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002758604910496},
isbn={978-989-674-018-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: Special Session on Neural Signals of Brain Disorde, (BIOSTEC 2010)
TI - CEREBRAL CORRELATES OF THE CONTINOUS PERFORMANCE TEST-IDENTICAL PAIRS VERSION - An fMRI Study
SN - 978-989-674-018-4
AU - M. Serra-Grabulosa J.
AU - Adan A.
AU - Falcón C.
AU - Bargalló N.
AU - Solé-Casals J.
PY - 2010
SP - 491
EP - 496
DO - 10.5220/0002758604910496