A TASTE OF YEAST MOBILOMICS
Giulia Menconi, Giovanni Battaglia, Roberto Grossi, Nadia Pisanti, Roberto Marangoni
2012
Abstract
Mobilomics calls for detecting all the mobile elements in a genome so as to understand their dynamic behavior. We devise and apply a method that extends a pairwise strain comparison tool for mobile genetic elements (MGE) inference, and perform experiments on a whole dataset of 39 complete genomes of as many yeast (S.cerevisiae) strains. We locate a priori all the MGEs regions that are annotated in the reference sequence at hand, and map all the putative MGEs in all the other (non-annotated) strains. Interestingly, evolutionary relation among the strains based on the presence/absence of candidate MGEs, turns out to be quite close to that inferred by classic phylogenetic methods based on SNPs analysis.
References
- Bennetzen, J. (2000). Transposable elements contribution to plant gene and genome evolution. Plant Mol Biol, 42:251-269.
- Bourque, G. (2009). Transposable elements in gene regulation and in the evolution of vertebrate genomes. Current Opinion in Genetics and Development, 19:607- 612.
- Brittten, R. (2010). Transposable element insertions have strongly affected human evolution. PNAS, 107:19945-19948.
- Di Rienzi, S., Collingwood, D., Raghuraman, M., and Brewer, B. (2010). Fragile genomic sites are associated with origins of replication. Genome Biology and Evolution, 1(0):350.
- Fachinetti, D., Bermejo, R., Cocito, A., Minardi, S., Katou, Y., Kanoh, Y., Shirahige, K., Azvolinsky, A., Zakian, V., and Foiani, M. (2010). Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements. Molecular Cell, 39(4):595-605.
- Gerton, J., DeRisi, J., Shroff, R., Lichten, M., Brown, P., and Petes, T. (2000). Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 97(21):11383.
- Jones, E., Oliphant, T., Peterson, P., et al. (2001). SciPy: Open source scientific tools for Python.
- Kazian, H. H. (2004). Mobile elements: Drivers of genome evolution. Science, 303:1626-1632.
- Kidwell, M. G. and Lisch, D. R. (2001). Perspective: transposable elements, parasitic dna, and genome evolution. Evolution, 55:1-24.
- Koszul, R., Caburet, S., Dujon, B., and Fischer, G. (2004). Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments. EMBO J., 23:234-243.
- Leonardo, T. and Nuzhdin, S. (2002). Mobile elements and disease. Genet Res, 80:155-161.
- Liti, G., Carter, D. M., Moses, A. M., and et al. (2009). Population genomics of domestic and wild yeast. Nature, 458:337-341.
- Menconi, G., Battaglia, G., Grossi, R., Pisanti, N., and Marangoni, R. (2011). Inferring mobile elements in S.cerevisiae strains. In International Conference on Bioinformatics Models, Methods and Algorithms. SciTePress. ISBN 978-989-8425-36-2.
- Rankin, D., Bichsel, M., and Wagner, A. (2010). Mobile dna can drive lineage extinction in prokaryotic populations. Journal of Evolutionary Biology, 23:2422- 2431.
- SGD (2010). Saccharomyces Genome Database. http:// www.yeastgenome.org/.
- Shao, Y., He, X., Harrison, E. M., Tai, C., Ou, H.-Y., Rajakumar, K., and Den, Z. (2010). mgenomesubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Research, 38:W194-W200.
- Siefert, J. L. (2009). Defining the mobilome. Methods in Molecular Biology, 532:13-27.
- Szilard, R., Jacques, P., Laramée, L., Cheng, B., Galicia, S., Bataille, A., Yeung, M., Mendez, M., Bergeron, M., Robert, F., et al. (2010). Systematic identification of fragile sites via genome-wide location analysis of g -H2AX. Nature Structural & Molecular Biology.
Paper Citation
in Harvard Style
Menconi G., Battaglia G., Grossi R., Pisanti N. and Marangoni R. (2012). A TASTE OF YEAST MOBILOMICS . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012) ISBN 978-989-8425-90-4, pages 271-274. DOI: 10.5220/0003702302710274
in Bibtex Style
@conference{bioinformatics12,
author={Giulia Menconi and Giovanni Battaglia and Roberto Grossi and Nadia Pisanti and Roberto Marangoni},
title={A TASTE OF YEAST MOBILOMICS},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)},
year={2012},
pages={271-274},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003702302710274},
isbn={978-989-8425-90-4},
}
in EndNote Style
TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)
TI - A TASTE OF YEAST MOBILOMICS
SN - 978-989-8425-90-4
AU - Menconi G.
AU - Battaglia G.
AU - Grossi R.
AU - Pisanti N.
AU - Marangoni R.
PY - 2012
SP - 271
EP - 274
DO - 10.5220/0003702302710274