ject is to use the system in a formal pilot trial, with a
select group of CFS/ME patients. The planned trial
would be performed in two stages as follows. In
stage one, an initial sample of five patients with the
condition will be offered traditional CBT, but will
use the ASARM system alongside the CBT and the
completion of paper diaries. Qualitative responses
from the use of the devices will also be captured.
This stage will lead to the development of a clini-
cal ASARM protocol which will subsequently be fol-
lowed for stage two, with a further 25 patients, as
well as allowing iterative refinement of the ASARM
system and software. All participants will use the
ASARM devices at the various stages of treatment:
assessment (establishment of baseline activity level),
early treatment phase and late treatment phase. Rele-
vant clinical outcome measures will also be collected,
pretreatment and post-treatment, as well as informa-
tion on the patient experience of the ASARM devices.
ACKNOWLEDGEMENTS
This work was funded by The Manchester Centre
for Integrating Medicine & Innovative Technology
(http://www.mimit.org.uk/).
REFERENCES
Abeles, P., Verduyn, C., Robinson, A., Smith, P., Yule, W.,
and Proudfoot, J. (2009). Computerized CBT for ado-
lescent depression (”stressbusters”) and its initial eval-
uation through an extended case series. Behavioural
and Cognitive Psychotherapy, 37(2):151–165.
Afari, N. and Buchwald, D. (2003). Chronic fatigue syn-
drome: a review. American Journal of Psychiatry,
60:221–226.
Avellaneda Fernandez, A., Perez Martin, A., Izquierdo Mar-
tinez, M., Arruti Bustillo, M., Barbado Hernandez,
F. J., de la Cruz Labrado, J., Diaz-Delgado Penas, R.,
Gutierrez Rivas, E., Palacin Delgado, C., Rivera Re-
dondo, J., and Ramon Gimenez, J. R. (2009). Chronic
Fatigue Syndrome: aetiology, diagnosis and treat-
ment. BMC Psychiatry, 9 Suppl 1:S1.
Farmer, A., Fowler, T., Scourfield, J., and Thapar, A.
(2004). Prevalence of chronic disabling fatigue in
children and adolescents. British Journal of Psychi-
atry, pages 477–481.
Fielding, R. T. (2000). Architectural Styles and the Design
of Network-based Software Architectures. PhD thesis,
University of California, Irvine.
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dob-
bins, J. G., and Komaroff, A. (1994). The Chronic
Fatigue Syndrome; A Comprehensive Approach to its
Definition and Study. Annals of Internal Medicine,
121:953–959.
Hinds, G. M. E. and McCluskey, D. R. (1993). A restrospec-
tive study of chronic fatigue syndrome. Proceedings
of the Royal College of Physicians, pages 10–14.
Jason, L., Richman, J. A., Rademaker, A., Jordan, K. M.,
Plioplys, A. V., Taylor, R. R., McCready, W., Huang,
C., and Plioplys, S. (1999). A community-based study
of Chronic Fatigue Syndrome. Archive of Internal
Medicine, 159:2129–2137.
Kop, W., Lyden, A., Berlin, A., Ambrose, K., Olsen, C.,
Gracely, R., Williams, D., and D.J., C. (2005). Ambu-
latory monitoring of physical activity and symptoms
in fibromyalgia and chronic fatigue syndrome. Arthri-
tis and Rheumatism, 52(1):296–303.
Lai, A. M., Nieh, J., and Starren, J. B. (2007). REPETE2:
A next generation home telemedicine architecture.
AMIA Annual Symposium Proceedings, 1020.
Lai, A. M., Starren, J. B., and Shea, S. (2005). Architec-
ture for remote training of home telemedicine patients.
AMIA Annual Symposium Proceedings, 1015.
National Institute of Clinical Excellence (NICE)
(2007). Chronic Fatigue Syndrome/Myalgic En-
cephalomyelitis (or Encephalopathy): diagnosis and
management of CFS/ME in adults and children.
http://www.nice.org.uk/CG53.
Reeves, W. C., Wagner, D., Nisenbaum, R., Jones, J. F.,
Gurbaxani, B., Solomon, L., Papanicolaou, D. A.,
Unger, E. R., Vernon, S. D., and Heim, C. (2005).
Chronic fatigue syndrome – a clinically empirical ap-
proach to its definition and study. BMC Medicine,
3(19).
Reyes, M., Nisenbaum, R., Hoaglin, D. C., Unger, E. R.,
Emmons, C., Randall, B., Stewart, J. A., Abbey, S.,
Jones, J. F., Gantz, N., Minden, S., and Reeves, W. C.
(2003). Prevalence and incidence of Chronic Fatigue
Syndrome in wichita, kansas. Archive of Internal
Medicine, 163:1530–1536.
Robinson, A., Yule, W., Verduyn, C., Smith, P., and Abeles,
J. P. P. (2011). Stressbusters: The development of a
computerised CBT programme for adolescent depres-
sion. In Yule, W. and Udwin, O., editors, Increasing
Access to CAMHS, volume 30, pages 45–50. ACAMH
Occasional Papers, Association For Child and Adoles-
cent Mental Health.
Royal College of Paediatrics and Child Health (2004).
Evidence based guidelines for the manage-
ment of CFS/ME in children and young people.
http://www.ayme.org.uk/article.php?sid=10&id=137.
Stulemeijer, M., de Jong, L. W. A. M., Fiselier, T. J. W.,
Hoogveld, S. W. B., and Bleijenberg, G. (2005). Cog-
nitive behaviour therapy for adolescents with chronic
fatigue syndrome: randomised controlled trial. Brit-
sish Medical Journal, pages 14–17.
White, P., Goldsmith, K. A., Johnson, A., and et al. (2011).
Comparison of adaptive pacing therapy, cognitive be-
haviour therapy, graded exercise therapy, and special-
ist medical care for chronic fatigue syndrome (pace):
a randomised trial. Lancet, pages 611–690.
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