A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth

Antonio Apicella, Raffella Aversa

2012

Abstract

The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating “scaffolds” to promote early regeneration in implanted bone healing phases. A biomometic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer-aided simulations have been carried out. Such multidisciplinary approach allowed us to explore many novel ideas in modelling, design and fabrication of new nanostructured biomaterials and scaffolds with enhanced functionality and improved interaction with OB cells. In vivo tests of Titanium screw implanted in rabbit tibiae have shown that mechanical stimulation was induced by the presence of bioactive hybrid perimplantar scaffold resulting in a differentiation and development of mesenchymal tissues. In order to investigate the relationship between bone growth and applied mechanical loading (strain), a piezoelectically driven cantilever and a computer-controlled apparatus for "in vitro" tests has been developed and presented.

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Paper Citation


in Harvard Style

Apicella A. and Aversa R. (2012). A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 280-285. DOI: 10.5220/0003887902800285


in Bibtex Style

@conference{biodevices12,
author={Antonio Apicella and Raffella Aversa},
title={A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={280-285},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003887902800285},
isbn={978-989-8425-91-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth
SN - 978-989-8425-91-1
AU - Apicella A.
AU - Aversa R.
PY - 2012
SP - 280
EP - 285
DO - 10.5220/0003887902800285