Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation

J. Milenkovic, A. H. Alexopoulos, C. Kiparissides

2012

Abstract

In this work the steady-state flow in a commercial dry powder inhaler device (i.e., Turbuhaler) is described. The DPI geometry is constructed in a CAD/CAM environment (i.e., CATIA v5) and then imported into GAMBIT where the geometry is discretized into a computational grid. The Navier-Stokes equations are solved using FLUENT (v6.3) considering different flow models, i.e., laminar, k-ε, k-ε RNG, and k-ω SST. Particle motion and deposition are described using an Eulerian-fluid/Lagrangian-particle approach. Flow and particle deposition for a range of mouthpiece pressure drops (i.e., 800-8800Pa), as well as particle sizes corresponding to single particles and aggregates (i.e., 0.5-20μm) are examined. The total volumetric outflow rate, the overall particle deposition as well as the particle deposition sites in the DPI are determined. The transitional k-ω SST model for turbulent flow was found to produce results most similar to a reference Large Eddy Simulation solution as well as experimental results for the pressure drop in the DPI. Realistic particle deposition results could only be obtained by considering a nonideal sticking coefficient corresponding to a critical capture velocity of 2.7m/s. Overall, the simulation results are found to agree well with available experimental data for volumetric flow and particle deposition.

References

  1. Abdelrahim, M. E., (2010) Emitted dose and lung deposition of inhaled terbutaline from Turbuhaler at different conditions, Respiratory Medicine, 104, 682- 689.
  2. Alagusundaram M., N. Deepthi, S. Ramkanth, S. Angalaparameswari, T. S. M. Saleem, K. Gnanaprakash, V. S. Thiruvengadarajan, C. Madhusudhana, C. M. Alagusundaram et al., (2010) Dry Powder Inhalers - An Overview, Int. J. Res. Pharm. Sci., 1(1), 34-42.
  3. Ashurst I., A. Malton, D. Prime and B. Sumby, (2000) Latest advances in the development of dry powder inhalers, PSTT, 3(7), 246-256.
  4. Brach RM, Dunn P.F (1992). A Mathematical Model of Impact and Adhesion of Microspheres. Aerosol Sci. Technol., 23, 51-71.
  5. Calvert G., A. Hassanpour, M. Ghadiri, (2011) Mechanistic analysis and computer simulation of the aerodynamic dispersion of loose aggregates, Chemical Engineering Research and Design, 89, 519-525.
  6. Chan H-K, (2006) Dry powder aerosol drug delivery - Opportunities for colloid and surface scientists, Colloids and Surfaces A: Physicochem. Eng. Aspects, 284-285, 50-55.
  7. Coates M. S., D. F. Fletcher, H-K. Chan and J. A. Raper, (2004) Effect of Design on the Performance of a Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure and Mouthpiece Length, J. of Pharmaceutical Sciences, 93, 2863-2876.
  8. Coates M. S., H-K Chan, D. F. Fletcher and J. A. Raper, (2005) Influence of Air Flow on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses, Pharmaceutical Research, 22(9), 923-932.
  9. Coates M. S., H-K. Chan, D. F. Fletcher and J. A. Raper, (2006) Effect of Design on the Performance of a Dry Powder Inhaler Using Computational Fluid Dynamics. Part 2: Air Inlet Size, J. of Pharmaceutical Sciences, 95(6), 1382-1392.
  10. de Koning J. P., M. R. Visser, G. A. Oelen, A. H. de Boer, ThW van der Mark, P. M. J. Coenegracht, ThFJ Tromp and H. W. Frijlink, (2001) Effect of Peak Inspiratory Flow and Flow Increase Rate on In Vitro Drug Deposition from Four Dry Powder Inhaler Devices, in Dry Powder Inhalation: Technical and Physiological Aspects, Prescribing and Use, Thesis, Rijksuniversiteit Groningen, Ch. 6., 83-94.
  11. Finlay W., (2001) The Mechanics of Inhaled Pharmaceutical Aerosols. An Introduction, Academic Press, London.
  12. French D. L., D. A. Edwards and R. W. Niven, (1996) The Influence of Formulation on Emission Deaggregation and Deposition of Dry Powders for Inhalation, J. Aerosol Sci., 27(5), 769-783.
  13. Hoe S., D. Traini, H-K. Chan, P. M. Young, (2009) Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI), European J. of Pharmaceutical Science, 38, 88-94.
  14. Islam N. and E. Gladki, (2008) Dry powder inhalers (DPIs) - A review of device reliability and innovation, Int. J. of Pharmaceutics, 360, 1-11.
  15. Ligotke M. W., (2002) Development and characterization of a dry powder inhaler. In: Dalby RN, Byron PR, Peart J, Farr SJ, editors. Respiratory drug delivery VIII, vol. I. Tucson, AZ: Serentec Press Inc., 419-422.
  16. Newman S. P. and W.W. Busse, (2002) Evolution of dry powder inhaler design, formulation, and performance, Respir Med., 96(5), 293-304.
  17. Olsson et al.: Patent Application Publication. Pub. No. US 2007/0107721 A1. Pub. Date: May, 17, 2007.
  18. Schuler C., A. Bakshi, D. Tuttle, A. Smith, S. Paboojian, H. Snyder, D. Rasmussen, A. Clark, (1999) Inhale's dry-powder pulmonary drug delivery system: Challenges to current modeling of gas-solid flows. In: Proceedings of FEDSM99: 3rd ASME/JSME joint fluids engineering conference and 1999 ASME Fluids Engineering summer meeting, FEDSM99-7895.
  19. Tobyn M., J. N. Staniforth, D. Morton, Q. Harmer and M. E. Newton, (2004) Active and intelligent inhaler device development, Int. J. of Pharmaceutics 277, 31- 37.
  20. Tong Z. B., R. Y. Yang, K. W. Chu, A. B. Yu, S. Adi, HK. Chan, (2010) Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow, Chemical Engineering Journal 164, 432-441.
  21. Tsima M. P., G. P. Martin, C. Marriott, D. Gardenton and M. Yianneskis, (1994) Drug delivery to the respiratory tract using dry powder inhaler, Int. J. of Pharmaceutics, 101, 1-13.
  22. Wetterlin K., (1988) Turbuhaler: A New Powder Inhaler for Administration of Drugs to the Airways. Pharmaceutical Research, 5(8), 506-508.
  23. Zeng X-M, G. P. Martin, C. Marriott and J. Pritchard, (2000) The influence of carrier morphology on drug delivery by dry powder inhalers, Int. J. of Pharmaceutics, 200, 93-106.
Download


Paper Citation


in Harvard Style

Milenkovic J., H. Alexopoulos A. and Kiparissides C. (2012). Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation . In Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH, ISBN 978-989-8565-20-4, pages 250-259. DOI: 10.5220/0004058102500259


in Bibtex Style

@conference{simultech12,
author={J. Milenkovic and A. H. Alexopoulos and C. Kiparissides},
title={Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation},
booktitle={Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH,},
year={2012},
pages={250-259},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004058102500259},
isbn={978-989-8565-20-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH,
TI - Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation
SN - 978-989-8565-20-4
AU - Milenkovic J.
AU - H. Alexopoulos A.
AU - Kiparissides C.
PY - 2012
SP - 250
EP - 259
DO - 10.5220/0004058102500259