A Linked Data Approach for Querying Heterogeneous Sources - Assisting Researchers in Finding Answers to Complex Clinical Questions
Nikolaos Matskanis, Vassiliki Andronikou, Philippe Massonet, Kostas Mourtzoukos, Joseph Roumier
2012
Abstract
Clinical trials for drug repositioning aim at evaluating the effectiveness and safety of existing drugs as new treatments. This involves managing and semantically correlating many interdependent parameters and details in order to clearly identify the research question of the clinical trial. This work, which is carried out within the PONTE (Efficient Patient Recruitment for Innovative Clinical Trials of Existing Drugs) project, aims to improve the trial design process, by not only offering access to a variety of relevant data sources – including, but not limited to, drug profiles, diseases and their mechanisms, genes and past trial results – but also providing the ability to navigate through these sources, perform queries on them and intelligently fuse the available information through semantic reasoning. This article describes our intention to consume and aggregate information from Linked Data sources in order to produce answers for the clinical researcher’s questions.
References
- Ashburn, T., Thor, K., 2004. Drug repositioning: identifying and developing new uses for existing drugs. Nature reviews. Drug discovery.
- Belleau, F., Nolin, M. A., Tourigny, N., Rigault, P., Morissette, J., 2008. Bio2RDF: towards a mashup to build bioinformatics knowledge systems, Journal of biomedical informatics, S.706-716,
- Berners-Lee, T. 2006. Linked Data - Design Issues. http:// www.w3.org/DesignIssues/LinkedData.html
- Bizer C., T., Heath, T., Berners-Lee, T., 2010. Linked data-the story so far, sbc, S.9
- Bouquet, P., Ghidini, C., Serafini, L., 2009. Querying the Web of Data: A formal approach. In Proc of the 4th Asian Semantic Web Conference (ASWC).
- Chondrogiannis, E., Matskanis, N., Roumier, J., Massonet, P., Andronikou, V., 2011, Enabling semantic interlinking of medical data sources and EHRs for clinical research purposes, eChallenges conference
- Hartig, O., Bizer, C, Freytag, J. C., 2009. Executing SPARQL Queries over the Web of Linked Data, In Proceedings of the 8th International Semantic Web Conference (ISWC), Washington, DC, USA.
- Hartig, O., Freytag, J. C., 2012: Foundations of Traversal Based Query Execution over Linked Data. In Proceedings of the 23rd ACM Conference on Hypertext and Social Media (HT), Semantic Data Track, Milwaukee, WI, USA
- Samwald, M., Jentzsch, A., Bouton, C., Kallesøe, C. S., Willighagen, E., Hajagos, J., Marshall, M. S., Prud'hommeaux, E., Hassanzadeh, O., Pichler, E., Stephens, S., 2011. Linked open drug data for pharmaceutical research and development, Journal of Cheminformatics, 3:19 doi:10.1186/1758-2946-3-19
- Schmidt, M., et al., 2011. FedBench: A Benchmark Suite for Federated Semantic Data Query Processing, ISWC
Paper Citation
in Harvard Style
Matskanis N., Andronikou V., Massonet P., Mourtzoukos K. and Roumier J. (2012). A Linked Data Approach for Querying Heterogeneous Sources - Assisting Researchers in Finding Answers to Complex Clinical Questions . In Proceedings of the International Conference on Knowledge Engineering and Ontology Development - Volume 1: KEOD, (IC3K 2012) ISBN 978-989-8565-30-3, pages 411-414. DOI: 10.5220/0004173004110414
in Bibtex Style
@conference{keod12,
author={Nikolaos Matskanis and Vassiliki Andronikou and Philippe Massonet and Kostas Mourtzoukos and Joseph Roumier},
title={A Linked Data Approach for Querying Heterogeneous Sources - Assisting Researchers in Finding Answers to Complex Clinical Questions},
booktitle={Proceedings of the International Conference on Knowledge Engineering and Ontology Development - Volume 1: KEOD, (IC3K 2012)},
year={2012},
pages={411-414},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004173004110414},
isbn={978-989-8565-30-3},
}
in EndNote Style
TY - CONF
JO - Proceedings of the International Conference on Knowledge Engineering and Ontology Development - Volume 1: KEOD, (IC3K 2012)
TI - A Linked Data Approach for Querying Heterogeneous Sources - Assisting Researchers in Finding Answers to Complex Clinical Questions
SN - 978-989-8565-30-3
AU - Matskanis N.
AU - Andronikou V.
AU - Massonet P.
AU - Mourtzoukos K.
AU - Roumier J.
PY - 2012
SP - 411
EP - 414
DO - 10.5220/0004173004110414