Continuous Nasal Airflow Resistance during Birch Pollen Provocation Test

Tiina M. Seppänen, Olli-Pekka Alho, Aleksi Laajala, Elina Rahkola, Tapio Seppänen

2013

Abstract

Even 50% of population suffers from allergic symptoms in some countries. There is a need for an objective measurement method giving an accurate, reliable and continuous measurement data about the dynamic nasal function. A novel method to assess unobtrusively the continuous nasal airflow resistance using calibrated respiratory belts is used to produce a continuous nasal airflow resistance during the birch pollen provocation test. Ten birch pollen allergic and eleven non-allergic volunteers were recruited and measured. A statistically significant change in the nasal airflow resistance was found due to the challenge in the allergic group while no statistically significant change was found in the non-allergic group. Unique continuous nasal airflow resistance curves were derived to show the dynamic changes in the nasal airflow resistance during the provocation test. The continuous curves show in great detail fast and slow reactions to nasal provocations, which may be helpful in studying the reactivity of patients. The presented method could increase the reliability and accuracy of diagnostics and assessment of the effect of nasal treatments.

References

  1. Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias A., et al., 2008. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update (in collaboration with the World Healt Organization, GA2LEN and AllerGen). Allergy, 63(Suppl 86), pp. 8-160.
  2. Chaaban, M., and Corey, J. P., 2011. Assessing nasal air flow: options and utility. Proceedings of the American Thoracic Society, vol 8 March no. 1, pp. 70-78.
  3. Hohlfeld, J.M., Holland-Letz, T., Larbig, M., LavaeMokhtari, M., Wierenga, E., Kapsenberg, M., van Ree, R., Krug, N., and Bufe, A., 2010. Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions. Clinical & Experimental Allergy, vol 40 issue 7, pp. 998-1006.
  4. Kohler, M., Thurnheer, R., and Bloch, K. E., 2006. Sideselective, unobtrusive monitoring of nasal airflow and conductance. Journal of Applied Physiology, 101, pp. 1760-1765.
  5. Naito, K., Iwata, S., Ohoka, E., Kondo, Y., and Taekuchi, M., 1993. A comparison of current expressions of nasal patency. European Archives of Oto-RhinoLaryngology, 250, pp. 249-252.
  6. Pirilä, T., Talvisara, A., Alho, O-P, and Oja, H., 1997. Physiological fluctuations in nasal resistance may interfere with nasal monitoring in the nasal provocation test. Acta Oto-laryngologica, 117, pp. 596-600.
  7. Pirilä, T., and Nuutinen, J., 1998. Acoustic rhinometry, rhinomanometry and the amount of nasal secretion in the clinical monitoring of the nasal provocation test. Clinical & Experimental Allergy, vol 28 issue 4, pp. 468-477.
  8. Seppänen, T., Koskinen, M., Seppänen, T. M., and Alho, O-P, 2009. Continuous assessment of nasal airflow resistance by adaptive modeling. Physiological Measurement, vol. 30, pp. 1197-1209.
  9. Seppänen, T., Koskinen, M., Seppänen, T. M., and Alho, O-P, 2010. Addendum to Continuous assessment of nasal airflow resistance by adaptive modeling - technical repeatability. Physiological Measurement, vol. 31, pp. 1547-1551.
  10. Seppänen, T. M., Alho, O-P, Koskinen, M., and Seppänen, T., 2011. Improved calibration method of respiratory belts by extension of multiple linear regression. Proceedings of the 5th European Conference of the International Federation for Medical and Biological Engineering, 37:161-164.
  11. Tobin, M., 1992. Breathing pattern analysis. Intensive Care Medicine, 18, pp. 193-201.
Download


Paper Citation


in Harvard Style

M. Seppänen T., Alho O., Laajala A., Rahkola E. and Seppänen T. (2013). Continuous Nasal Airflow Resistance during Birch Pollen Provocation Test . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013) ISBN 978-989-8565-36-5, pages 5-10. DOI: 10.5220/0004181300050010


in Bibtex Style

@conference{biosignals13,
author={Tiina M. Seppänen and Olli-Pekka Alho and Aleksi Laajala and Elina Rahkola and Tapio Seppänen},
title={Continuous Nasal Airflow Resistance during Birch Pollen Provocation Test},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)},
year={2013},
pages={5-10},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004181300050010},
isbn={978-989-8565-36-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)
TI - Continuous Nasal Airflow Resistance during Birch Pollen Provocation Test
SN - 978-989-8565-36-5
AU - M. Seppänen T.
AU - Alho O.
AU - Laajala A.
AU - Rahkola E.
AU - Seppänen T.
PY - 2013
SP - 5
EP - 10
DO - 10.5220/0004181300050010