Modelling of Genetic Interactions in GWAS Reveals More Complex Relations between Genotype and Phenotype

Joanna Zyla, Christophe Badie, Ghazi Alsbeih, Joanna Polanska

2014

Abstract

The aim of this work is to present the complete methodology useful in GWAS analysis with small sample size, where comprehension of interaction between the genotype and phenotype is a main issue. By including all possible models of interaction into the process of model building, we were able to significantly increase the number of candidate polymorphisms and decrease the false discovery ratio.

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Paper Citation


in Harvard Style

Zyla J., Badie C., Alsbeih G. and Polanska J. (2014). Modelling of Genetic Interactions in GWAS Reveals More Complex Relations between Genotype and Phenotype . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014) ISBN 978-989-758-012-3, pages 204-208. DOI: 10.5220/0004807402040208


in Bibtex Style

@conference{bioinformatics14,
author={Joanna Zyla and Christophe Badie and Ghazi Alsbeih and Joanna Polanska},
title={Modelling of Genetic Interactions in GWAS Reveals More Complex Relations between Genotype and Phenotype},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)},
year={2014},
pages={204-208},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004807402040208},
isbn={978-989-758-012-3},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)
TI - Modelling of Genetic Interactions in GWAS Reveals More Complex Relations between Genotype and Phenotype
SN - 978-989-758-012-3
AU - Zyla J.
AU - Badie C.
AU - Alsbeih G.
AU - Polanska J.
PY - 2014
SP - 204
EP - 208
DO - 10.5220/0004807402040208