An Automated Medical Device for Ultimate ABO Compatibility Test at the Patient’s Bedside - Towards the Automation of Point-of-care Transfusion Safety

Karine Charrière, Alain Rouleau, Olivier Gaiffe, Pascal Morel, Véronique Bourcier, Christian Pieralli, Wilfrid Boireau, Lionel Pazart, Bruno Wacogne

2015

Abstract

In blood transfusion, accidents still occur because of ABO mismatch between donor and patient’s blood. These errors, sometimes lethal, are principally due to wrong identification of patient and/or blood product or to human errors. The best way to avoid these errors is to perform an ultimate ABO compatibility test at the patient’s bedside immediately prior to transfusion. Ideally, this test should be performed automatically, without human interpretation and with minimum blood exposure for nurses. This ideal and ultimate method is not yet employed because of the lack of suitable device. In this paper, we propose a system that may fulfil the above mentioned requirements. It is based on selective blood capture on biochip surfaces in a device which automatically drives the different fluids, performs optical detection of captured red cells and finally interprets the optical reading in terms of ABO compatibility. So far, our device achieved blood compatibility test with 99.3 % sensitivity and 97.9 % specificity.

References

  1. ANSM, 2012 and 2014. Rapport d'activité hémovigilance. http://ansm.sante.fr/Mediatheque/Publications/BilansRapports-d-activite-Bilans-et-rapports-dactivite#folder_26762.
  2. Berthier, A., Elie-Caille, C., Lesniewska, E., DelageMourroux, R., Boireau, W., 2011. Label-free sensing and atomic force spectroscopy for the characterization of protein-DNA and protein-protein interactions: application to estrogen receptors, J. Mol. Recognit. JMR. 24, p.429-435.
  3. Boozer, C., Kim, G., Cong, S., Guan, H., Londergan, T., 2006. Looking towards label-free biomolecular interaction analysis in a high-throughput format: a review of new surface plasmon resonance technologies, Curr. Opin. Biotechnol. 17, p. 400-405.
  4. Campbell, C., Kim, G., 2007. SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics, Biomaterials. 28, p. 2380-2392.
  5. Charrière, K., Guerrini-Chapuis, J.S., Wacogne, B., ElieCaille, C., Pieralli, C., Pazart, L., Morel, P., Boireau, W., 2011. SmartTransfuser: a lab-on-chip system for enhancing transfusion security", 2nd International Conference on Bio-sensing Technology, Amsterdam, The Nederlands.
  6. Charrière, K., Guerrini-Chapuis, J.S., Wacogne, B., ElieCaille, C., Pieralli, C., Pazart, L., Morel, P., Boireau, W., 2012. SmarTTransfuser - A Biochip System for the Final ABO Compatibility Test, in: SciTePress - Science and and Technology Publications, Vilamoura, p. 257-262.
  7. Cid, J., Nogués, N., Montero, R., Hurtado, M., Briega, A., Parra, R., 2006. Comparison of three microtube column agglutination systems for antibody screening: DG Gel, DiaMed-ID and Ortho BioVue, Transfus. Med. Oxf. Engl. 16 p. 131-136.
  8. EFS, 2012 and 2013. Rapport d'activité 2012, (2013). http://www.dondusang.net/rewrite/article/5592/l-efs/ publications/feuilletez-en-ligne-le-rapport-d-activite2012-de-l-efs.htm?idRubrique=790.
  9. Ferraz, A., Carvalho, V., Soares, F., 2010. Development of a Human Blood Type Detection Automatic System, in: B. Jakoby, M.J. Vellekoop (Eds.), Eurosensors Xxiv Conf., Elsevier Science Bv, p. 496-499.
  10. Ferraz,, A., Carvalho, V., 2013. A Prototype for Blood Typing Based on Image Processing, in: SENSORDEVICES 2013 Fourth Int. Conf. Sens. Device Technol. Appl., p. 139-144.
  11. Houngkamhang, N., Vongsakulyanon, A., Peungthum, P., Sudprasert, K., Kitpoka, P., Kunakorn, M., et al., 2013. ABO Blood-Typing Using an Antibody Array Technique Based on Surface Plasmon Resonance Imaging, Sensors, 13 p. 11913-11922.
  12. Krupin, O., Wang, C., Berini, P., 2014. Selective capture of human red blood cells based on blood group using long-range surface plasmon waveguides, Biosens. Bioelectron. 53, p. 117-122.
  13. Langston, M.M., Procter, J.L., Cipolone, K.M., Stroncek, D.F., 1999. Evaluation of the gel system for ABO grouping and D typing, Transfusion (Paris), 39, p. 300-305.
  14. Malomgre, W., Neumeister, B., 2009. Recent and future trends in blood group typing, Anal Bioanal Chem., 393, p. 1443-1451.
  15. Mansuy-Schlick, V., Delage-Mourroux, R., Jouvenot, M., Boireau, W., 2006. Strategy of macromolecular grafting onto a gold substrate dedicated to proteinprotein interaction measurements, Biosens. Bioelectron., 21, p. 1830-1837.
  16. Quinn, J.G., O'Neill, S., Doyle, A., McAtamney, C., Diamond, D., MacCraith, B.D. et al., 2000. Development and Application of Surface Plasmon Resonance-Based Biosensors for the Detection of Cell-Ligand Interactions, Anal. Biochem., 281, p. 135-143.
  17. Quinn, J.G., O'Kennedy, R., Smyth, M., Moulds, J., Frame, T., 1997. Detection of blood group antigens utilising immobilised antibodies and surface plasmon resonance, J. Immunol. Methods., 206, p. 87-96.
  18. Ramasubramanian, M., Anthony, S., Lambert, J., 2008. Simplified spectrophotometric method for the detection of red blood cell agglutination, Appl. Opt., 47, p. 4094-4105.
  19. Ramasubramanian, M.K., Alexander, S.P., 2009. An integrated fiberoptic-microfluidic device for agglutination detection and blood typing, Biomed. Microdevices, 11, p. 217-229.
  20. Steiner, G., 2004. Surface plasmon resonance imaging, Anal. Bioanal. Chem., 379, p. 328-331.
  21. Pazart, L., Wacogne, B., Pieralli, C., Boireau, W., Morel, P.,2011. Device for taking a sample of a body fluid and method for implementing same, WO 2011055029.
  22. Pazart, L., Wacogne, B., Pieralli, C., Boireau, W., Morel, P., 2011. Secure perfusion system. WO 2011055031.
Download


Paper Citation


in Harvard Style

Charrière K., Rouleau A., Gaiffe O., Morel P., Bourcier V., Pieralli C., Boireau W., Pazart L. and Wacogne B. (2015). An Automated Medical Device for Ultimate ABO Compatibility Test at the Patient’s Bedside - Towards the Automation of Point-of-care Transfusion Safety . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015) ISBN 978-989-758-071-0, pages 58-67. DOI: 10.5220/0005248700580067


in Bibtex Style

@conference{biodevices15,
author={Karine Charrière and Alain Rouleau and Olivier Gaiffe and Pascal Morel and Véronique Bourcier and Christian Pieralli and Wilfrid Boireau and Lionel Pazart and Bruno Wacogne},
title={An Automated Medical Device for Ultimate ABO Compatibility Test at the Patient’s Bedside - Towards the Automation of Point-of-care Transfusion Safety},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)},
year={2015},
pages={58-67},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005248700580067},
isbn={978-989-758-071-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)
TI - An Automated Medical Device for Ultimate ABO Compatibility Test at the Patient’s Bedside - Towards the Automation of Point-of-care Transfusion Safety
SN - 978-989-758-071-0
AU - Charrière K.
AU - Rouleau A.
AU - Gaiffe O.
AU - Morel P.
AU - Bourcier V.
AU - Pieralli C.
AU - Boireau W.
AU - Pazart L.
AU - Wacogne B.
PY - 2015
SP - 58
EP - 67
DO - 10.5220/0005248700580067