The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat

Irfan Idris, Aryadi Arsyad, A. Wardihan Sinrang, Syarifuddin Alwi

2017

Abstract

Abstract: ET-1 and its receptors (ETA & ETB) play a pivotal role in many diseases following obesity. The dynamic relation between ET-1 and its receptor in obesity is still rarely studied. The aim of this study is to know the profile of ET-1 and its receptors in young and adult obese wistar rat. Two groups of wistar rat (young and adult rat) involved in study with obese rat and normal weight rat as a control group respectively. ET-1 plasma, ETA receptor and ETB receptor of heart and kidney was determined by ELISA. The data showed that ET-1 plasma higher (p<0.05) in adult compare to young rat in obese and control group, ETA of heart and kidney of adult rat lower (p>0.05) than young rat in obese and control group, ETB of heart of adult rat lower (p<0.05) than young rat in obese and control group, and ETB of kidney higher (p>0,05) in adult rat than young rat in control group. The ET-1 plasma level tends to increase in adult rat compare to young rat in both group, while the expression of ETA and ETB receptor are different in both group

Paper Citation

in Harvard Style

Idris I., Arsyad A., Wardihan Sinrang A. and Alwi S. (2017). The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 147-150. DOI: 10.5220/0007334501470150

in Bibtex Style

@conference{sips17,
author={Irfan Idris and Aryadi Arsyad and A. Wardihan Sinrang and Syarifuddin Alwi},
title={The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={147-150},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007334501470150},
isbn={978-989-758-340-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - The Profile of Endothelin-1 (Et-1), Receptor ETA, And Receptor ETB in Young and Adult Obese Wistar Rat
SN - 978-989-758-340-7
AU - Idris I.
AU - Arsyad A.
AU - Wardihan Sinrang A.
AU - Alwi S.
PY - 2017
SP - 147
EP - 150
DO - 10.5220/0007334501470150