Effect of Growth Hormone Deficiency on the Cardiovascular System

Irma Magfirah, Soebagijo Adi Soelistijo, Hermina Novida, Deasy Ardiany

2017

Abstract

Growth hormone (GH) is a hormone responsible for the regulation of somatic cell growth, including the development of the heart and blood vessels, and their functions. GH deficiency is a clinical condition characterized by impaired activity, decreased quality of life, as well as the impaired composition of substances in the body. GH improves cardiac metabolism, reduces oxygen consumption and energy requirements, even in patients with heart failure who have increased wall stress and impaired glucose metabolism that is characterized by insulin resistance and fasting hyperinsulinemia. Patients with GH deficiency also suffer from abnormalities in coagulation factors, such as increased levels. In another study, young adult patients with GH deficiency were found to experience a decrease in left ventricular mass, decreased ejection fraction, as well as abnormal diastolic filling patterns. GH therapy significantly reduces low-density lipoprotein (LDL) cholesterol but does not affect triglyceride (TG). Growth hormone deficiency can increase the risk of cardiovascular disease by affecting the prevalence of risk factor-related events, such as central obesity, fat, and carbohydrate metabolism disorders, increased proinflammatory cytokines, endothelial dysfunction and oxidative stress, and morphological and cardiac dysfunction.

Paper Citation

in Harvard Style

Magfirah I., Adi Soelistijo S., Novida H. and Ardiany D. (2017). Effect of Growth Hormone Deficiency on the Cardiovascular System.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 342-348. DOI: 10.5220/0007338903420348

in Bibtex Style

@conference{sips17,
author={Irma Magfirah and Soebagijo Adi Soelistijo and Hermina Novida and Deasy Ardiany},
title={Effect of Growth Hormone Deficiency on the Cardiovascular System},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={342-348},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007338903420348},
isbn={978-989-758-340-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - Effect of Growth Hormone Deficiency on the Cardiovascular System
SN - 978-989-758-340-7
AU - Magfirah I.
AU - Adi Soelistijo S.
AU - Novida H.
AU - Ardiany D.
PY - 2017
SP - 342
EP - 348
DO - 10.5220/0007338903420348