Effect of Ethanol Extract of Ruellia tuberosa L. Leaves on Total Cholesterol Levels in Hypercholesterolemia Model of Mus Musculus L

Nurin Kusuma Dewi, Siti Khaerunnisa, Danti Nur Indriastuti

2017

Abstract

Ruellia tuberosa L. is distributed in Indonesia. Ruellia tuberosa L. leaves contain flavonoid and saponin. This study aimed to determine the effect of ethanol extract of Ruellia tuberosa L. leaves with a variation of dose to decrease total cholesterol levels in the experimental animal of male white mice (Mus musculus L.). This research used 32 male mice (Mus musculus L.) as an in-vivo test. Thirty-two samples were divided into four groups: K0 (positive control), K1 (treatment of 7 mg/20 grams of weight), K2 (treatment of 14 mg/20 grams of weight), and K3 (treatment of 28 mg/20 grams of weight). Hypercholesterolemia was induced in normal mice by giving a high-fat diet for 21 days (three weeks). The extract and high-fat diet were given for 14 days (two weeks) later. The measurement of total cholesterol level was done at the end of this research (5th week) using a cholesterol strip-EasyTouch®GCU Meter. The total cholesterol level was 171.17±29.369 mg/dl (K0), 120.83±28.117 mg/dl (K1), 141.83±26.118 mg/dl (K2), and 182.20±42.973 mg/dl (K3). The total cholesterol level was decreased significantly (p < 0.05). The dosage effective to reduce total cholesterol level was 7 mg/20 grams of weight

Paper Citation

in Harvard Style

Dewi N., Khaerunnisa S. and Indriastuti D. (2017). Effect of Ethanol Extract of Ruellia tuberosa L. Leaves on Total Cholesterol Levels in Hypercholesterolemia Model of Mus Musculus L.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 512-516. DOI: 10.5220/0007341505120516

in Bibtex Style

@conference{sips17,
author={Nurin Kusuma Dewi and Siti Khaerunnisa and Danti Nur Indriastuti},
title={Effect of Ethanol Extract of Ruellia tuberosa L. Leaves on Total Cholesterol Levels in Hypercholesterolemia Model of Mus Musculus L},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={512-516},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007341505120516},
isbn={978-989-758-340-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - Effect of Ethanol Extract of Ruellia tuberosa L. Leaves on Total Cholesterol Levels in Hypercholesterolemia Model of Mus Musculus L
SN - 978-989-758-340-7
AU - Dewi N.
AU - Khaerunnisa S.
AU - Indriastuti D.
PY - 2017
SP - 512
EP - 516
DO - 10.5220/0007341505120516