Effect of Quercetin on Growth and Mortality of High Fat-fed Drosophila Melanogaster

Nur Nazihah Binti Jainurin, Melanie Lim Boon Jin, Ameilia Zuliyanti Siregar, M. Mobin Siddique

2018

Abstract

Association of obesity with high fat diet is no longer debatable. Obesity causes hyperlipidemia and upregulates the generation of several metabolic by-products such as reactive oxygen species (ROS). Excess generation of ROS is toxic to the cell that often induces DNA damage and eventually induces cell death. Accumulation of lipid along with high level of ROS increase mortality and impair organisms’ growth. Herein, we have used Drosophila melanogaster as a model organism to assess the accumulation of lipid by commonly used dietary fat (commonly known as ghee) in Asia and its effect on the growth and mortality. Synthetic polyphenol, quercetin was used along with the high fat diet to address if this particular polyphenol can be used as a protective health supplement to minimize lipid-related toxicity. Our study suggests that high fat diet impairs the growth of D. melanogaster as detected by measuring total protein, whereas this is not affected by quercetin. It also appears that quercetin alone can induce high level of lipid accumulation and this is further enhanced in presence of dietary high fat (ghee) in these experimental flies.

Paper Citation

in Harvard Style

Binti Jainurin N., Boon Jin M., Siregar A. and Siddique M. (2018). Effect of Quercetin on Growth and Mortality of High Fat-fed Drosophila Melanogaster. In Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST, ISBN 978-989-758-496-1, pages 415-419. DOI: 10.5220/0010043904150419

in Bibtex Style

@conference{icest18,
author={Nur Nazihah Binti Jainurin and Melanie Lim Boon Jin and Ameilia Zuliyanti Siregar and M. Mobin Siddique},
title={Effect of Quercetin on Growth and Mortality of High Fat-fed Drosophila Melanogaster},
booktitle={Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,},
year={2018},
pages={415-419},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010043904150419},
isbn={978-989-758-496-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,
TI - Effect of Quercetin on Growth and Mortality of High Fat-fed Drosophila Melanogaster
SN - 978-989-758-496-1
AU - Binti Jainurin N.
AU - Boon Jin M.
AU - Siregar A.
AU - Siddique M.
PY - 2018
SP - 415
EP - 419
DO - 10.5220/0010043904150419