The Cytotoxicity of Paclitaxel Was Smaller than Doxorubicin in T47D Breast Cancer Cell

Irma Yanti Rangkuti

2018

Abstract

Breast cancer is a type of cancer commonly found by most women, ranking fifth leading cause of cancer worldwide cancer, consist of various subtypes. Chemotherapy is one of therapy in breast cancer patients but the benefit is not equal for all patients and paclitaxel is one of the most important chemotherapeutic drugs. The descriptive study had been done to paclitaxel and doxorubicin in T47D breast cancer cell. This study aimed to compare cytotoxic effect of paclitaxel and doxorubicin in T47D breast cancer cell, used paclitaxel concentrations 1000; 500; 250; 31,25; 15,625 nM and doxorubicin concentrations 500; 250;62,5;31,25;and 15,625 nM for 24 hours. This study was an invitro. The cytotoxic test used MTT method to determine IC50 and analized by SPSS. The result showed that IC50 paclitaxel was 1577,2 ± 115,3 nM and IC50 doxorubicin 202,37 ± 3,99 nM. The cytotoxicity of paclitaxel was smaller than doxorubicin in T47D breast cancer cell.

Paper Citation

in Harvard Style

Rangkuti I. (2018). The Cytotoxicity of Paclitaxel Was Smaller than Doxorubicin in T47D Breast Cancer Cell.In Proceedings of the 7th International Conference on Multidisciplinary Research - Volume 1: ICMR, ISBN 978-989-758-437-4, pages 171-176. DOI: 10.5220/0010061801710176

in Bibtex Style

@conference{icmr18,
author={Irma Yanti Rangkuti},
title={The Cytotoxicity of Paclitaxel Was Smaller than Doxorubicin in T47D Breast Cancer Cell},
booktitle={Proceedings of the 7th International Conference on Multidisciplinary Research - Volume 1: ICMR,},
year={2018},
pages={171-176},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010061801710176},
isbn={978-989-758-437-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 7th International Conference on Multidisciplinary Research - Volume 1: ICMR,
TI - The Cytotoxicity of Paclitaxel Was Smaller than Doxorubicin in T47D Breast Cancer Cell
SN - 978-989-758-437-4
AU - Rangkuti I.
PY - 2018
SP - 171
EP - 176
DO - 10.5220/0010061801710176