Association between VEGF-634G>C Gene Polymorphism with Degree of Neutrophil and Lymphocyte Infiltration in Helicobacter pylori Gastritis Patients

Zaimah Z. Tala, Gontar Alamsyah Siregar, Ginanda Putra Siregar

2018

Abstract

Previous study showed that VEGF-634G>C polymorphism was associated with VEGF expression. VEGF can enhance inflammatory processes, resulting in more severe inflammation. This study held to analyze association between VEGF -634G>C polymorphism and the degree of gastric neutrophil and lymphocyte infiltration in H. pylori gastritis patients. The aim of this study is to investigate association between VEGF - 634G>C polymorphism and the degree of gastric neutrophil and lymphocyte infiltration in H. pylori gastritis patients.This cross-sectional study included patients with H. pylori gastritis at Haji Adam Malik General Hospital, Permata Bunda General Hospital, and Universitas Sumatera Utara Hospital, Medan, Indonesia. Detection of H. pylori infection was made using positive results of 14C-UBT, and/ or rapid urease test. gaster. The degree of neutrophil and lymphocyte infiltrations were evaluated from biopsies of the mucosa gaster, referring to visual analogue scale of the updated Sydney System. Real time polymerase chain reaction (RT-PCR) was used to examine VEGF -634G>C gene polymorphism. Data were analyzed using SPSS version 22. There was significant association between VEGF-634 G>C polymorphism and degree of neutrophil infiltration. Patients with the G allele were at risk of 2.07 times for moderate + severe degree of neutrophil infiltration compared to C allele (p = 0.008). There was no significant association between VEGF -634 G>C polymorphism and degree of lymphocyte infiltration (p>0.05). G allele of VEGF- 634 G>C polymorphism was associated with moderate + severe neutrophil infiltration.

Paper Citation

in Harvard Style

Tala Z., Siregar G. and Siregar G. (2018). Association between VEGF-634G>C Gene Polymorphism with Degree of Neutrophil and Lymphocyte Infiltration in Helicobacter pylori Gastritis Patients.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 415-419. DOI: 10.5220/0010069904150419

in Bibtex Style

@conference{icosteerr18,
author={Zaimah Z. Tala and Gontar Alamsyah Siregar and Ginanda Putra Siregar},
title={Association between VEGF-634G>C Gene Polymorphism with Degree of Neutrophil and Lymphocyte Infiltration in Helicobacter pylori Gastritis Patients},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={415-419},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010069904150419},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Association between VEGF-634G>C Gene Polymorphism with Degree of Neutrophil and Lymphocyte Infiltration in Helicobacter pylori Gastritis Patients
SN - 978-989-758-449-7
AU - Tala Z.
AU - Siregar G.
AU - Siregar G.
PY - 2018
SP - 415
EP - 419
DO - 10.5220/0010069904150419