The Difference of Glutathione Peroxidase Levels among Chronic Atrophic Gastritis, Intestinal Metaplasia, and Dysplasia in Patients with Helicobacter pylori-associated Gastritis

Gontar Alamsyah Siregar, Masrul Lubis, Taufik Sungkar, Ginanda Putra Siregar, Darmadi

2018

Abstract

Helicobacter pylori infection is the main etiology of chronic gastritis. Chronic mucosal inflammation can lead to chronic atrophic gastritis, intestinal metaplasia, and gastric dysplasia. Oxidative stress plays a role in inflammatory and malignancy process. Glutathione peroxidase (GPX) levels will decrease due to oxidative stress. This study was conducted to evaluate the difference of GPX serum levels among chronic atrophic gastritis, intestinal metaplasia, and dysplasia in H. pylori-associated gastritis patients. A cross-sectional study on 70 consecutive gastritis patients who came to the endoscopic unit of Adam Malik General Hospital and Permata Bunda Hospital in Medan, Indonesia, from April – June 2018. The diagnosis of gastritis was derived histopathologically. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determined circulating GPX. Univariate and bivariate (Kruskal Wallis test) analysis were performed with SPSS version 22. There were 21 patients (30%) with chronic atrophic gastritis, 15 patients (21.4%) with intestinal metaplasia, and 8 patients (11.4%) with dysplasia. There were significant differences in GPX levels among chronic atrophic gastritis, intestinal metaplasia, and dysplasia (p = 0.037). GPX levels were significantly lower in patients with dysplasia than chronic atrophic gastritis. There were no significant difference in GPX levels between patients with intestinal metaplasia and chronic atrophic gastritis or dysplasia.

Paper Citation

in Harvard Style

Siregar G., Lubis M., Sungkar T., Siregar G. and Darmadi. (2018). The Difference of Glutathione Peroxidase Levels among Chronic Atrophic Gastritis, Intestinal Metaplasia, and Dysplasia in Patients with Helicobacter pylori-associated Gastritis.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 420-424. DOI: 10.5220/0010070004200424

in Bibtex Style

@conference{icosteerr18,
author={Gontar Alamsyah Siregar and Masrul Lubis and Taufik Sungkar and Ginanda Putra Siregar and Darmadi},
title={The Difference of Glutathione Peroxidase Levels among Chronic Atrophic Gastritis, Intestinal Metaplasia, and Dysplasia in Patients with Helicobacter pylori-associated Gastritis},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={420-424},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010070004200424},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - The Difference of Glutathione Peroxidase Levels among Chronic Atrophic Gastritis, Intestinal Metaplasia, and Dysplasia in Patients with Helicobacter pylori-associated Gastritis
SN - 978-989-758-449-7
AU - Siregar G.
AU - Lubis M.
AU - Sungkar T.
AU - Siregar G.
AU - Darmadi.
PY - 2018
SP - 420
EP - 424
DO - 10.5220/0010070004200424