Supplementation of Turmeric Extract Does Not Improve Neurological Function Following Repetitive Mild Traumatic Brain Injury in the Rat

Andre Marolop Pangihutan Siahaan, Iskandar Japardi

2018

Abstract

Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow coloring principle in turmeric, is a polyphenolic and a major active constituent. Besides the antiinflammatory, thrombolytic, and anti-carcinogenic, curcumin was also reported to have therapeutic potential in Alzheimer’s disease by inhibiting the amyloid--protein aggregation. Inflammation and early degeneration are two of main processes believed happened after repetitive mild traumatic brain injury. The effect of curcumin was evaluated in weight drop model of repetitive mild traumatic brain injury. Male Sprague dawley rats (n=10) were given multiple brain injury (40 gr mass drop from 1 m heights, 3 times daily on day 0,1,3, and 7). Curcumin (500 mg/kg) were given orally. On the last day of injury, psychomotor assessment (beam walk assessment and exit circle test) were performed. Control injured rats had a significant neurological deficit (p<0.01). No significant different found control and treatment group. The study does not demonstrate the efficacy of curcumin in rat with repetitive mild traumatic brain injury model.

Paper Citation

in Harvard Style

Siahaan A. and Japardi I. (2018). Supplementation of Turmeric Extract Does Not Improve Neurological Function Following Repetitive Mild Traumatic Brain Injury in the Rat.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 486-490. DOI: 10.5220/0010075504860490

in Bibtex Style

@conference{icosteerr18,
author={Andre Marolop Pangihutan Siahaan and Iskandar Japardi},
title={Supplementation of Turmeric Extract Does Not Improve Neurological Function Following Repetitive Mild Traumatic Brain Injury in the Rat},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={486-490},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010075504860490},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Supplementation of Turmeric Extract Does Not Improve Neurological Function Following Repetitive Mild Traumatic Brain Injury in the Rat
SN - 978-989-758-449-7
AU - Siahaan A.
AU - Japardi I.
PY - 2018
SP - 486
EP - 490
DO - 10.5220/0010075504860490