The Relationship between Tumor Necrosis Factor-Alpha (Tnf- Α) Serum Level and Negative Scale of PANSS in Smoking Schizophrenic Batak Men

Elmeida Effendy, Mustafa Mahmud Amin

2018

Abstract

Chronic schizophrenic patients characterized by non-remitting symptoms and functional decline over time suggest neuroprogression. Schizophrenia has the aberration in the proportion of immuno-competent cells and varied cytokine levels, particularly proinflammatory IL-6, IL-1 and TNF-α, in peripheral blood or cerebrospinal fluid. The negative symptoms of schizophrenia are characterized by deficits in normal emotions and social functions that can be primary or secondary to the treatment of the disease or other manifestations. TNF- α plays an important role in developing smoking-related illnesses, chronic obstructive pulmonary disease (COPD). Inhaling cigarette smoke can cause TNF-α production by alveolar macrophages, which in turn may increase the production of metalloproteinases (MMPs) involved in the mediation of salmon inflammation and lung damage. MMPs is involved in the mediation of respiratory inflammation and lung damage. This study aimed to determine the relationship between serum levels of TNF-α and PANSS negative scale in men with schizophrenia of Batak tribe smoking. This study was conducted at outpatient instalation RSJ. Prof. Dr. M. Ildrem Medan in the period of February 2018 - June 2018. This is an analytic numerical correlation with a cross-sectional approach. Subjects were 50 schizophrenic Batak men. The data analysis used Spearman correlation. The mean negative scale of PANSS is 30.42 ± 1.691. This shows that there is a negative symptom in schizophrenic patients. The mean TNF-α serum level was 22.31938 ± 23.242901. Spearman correlation coefficient between two variables is 0, 403 (p = 0.004). There was a significant correlation between serum levels of TNF-α and PANSS negative scale with a correlation value of 0.403 showing a positive correlation with moderate correlation strength (r = 0.4 - <0.6).

Paper Citation

in Harvard Style

Effendy E. and Amin M. (2018). The Relationship between Tumor Necrosis Factor-Alpha (Tnf- Α) Serum Level and Negative Scale of PANSS in Smoking Schizophrenic Batak Men.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 586-589. DOI: 10.5220/0010079605860589

in Bibtex Style

@conference{icosteerr18,
author={Elmeida Effendy and Mustafa Mahmud Amin},
title={The Relationship between Tumor Necrosis Factor-Alpha (Tnf- Α) Serum Level and Negative Scale of PANSS in Smoking Schizophrenic Batak Men},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={586-589},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010079605860589},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - The Relationship between Tumor Necrosis Factor-Alpha (Tnf- Α) Serum Level and Negative Scale of PANSS in Smoking Schizophrenic Batak Men
SN - 978-989-758-449-7
AU - Effendy E.
AU - Amin M.
PY - 2018
SP - 586
EP - 589
DO - 10.5220/0010079605860589