Effect of Ethanol Extract of Celery (Apium graveolens L) against Urea and Creatinine Level in Male Wistar Rats on Ethylene Glycol Induced Nephrolithiasis

Marline Nainggolan, Kasmirul Rumlan Sinaga, Siti Morin Sinaga, Sony Eka Nugraha

2018

Abstract

The use of celery in Indonesia was known as cooking spice to enrich the taste of food, has not been widely used as herbal medicine either in the form of juice or extract. The Pre-clinical testing of celery herbs in addition to diuretics it is also to treat sore eyes, sprains, rheumatism, hypertension, and as a hair tonic. The celery Herb is rich in the content of flavonoids and potassium that can be used to dilute kidney stones. The aim of this study was to investigate effect of ethanol extract of celery (Apium graveolens L) against urea and creatinine level in male wistar rats on ethylene glycol induced nephrolithiasis. In vivo test was performed male wistar which divided into 6 groups. Group I as normal control without any tratment, Group II as negative control was induced ethylene glycol, Group III as positive control was given Batugin Elixir, Group IV, V and VI were given ethanol extract of celery a dose of 50, 100 and 150 mg/kgBW respectively. Blood was collected by cardiac puncture then measured level of urea and creatinine. The data were analyzed statistically using ANOVA (analysis of variance). The results showed that ethanol extract of celery has an effective activity at a dose of 150 mg / kgBW (P < 0.05) to negative group in decreasing level of urea and creatinine male wistar rats on ethylene glycol induced nephrolithiasis and it showed a dose-dependent manner.

Paper Citation

in Harvard Style

Nainggolan M., Sinaga K., Sinaga S. and Nugraha S. (2018). Effect of Ethanol Extract of Celery (Apium graveolens L) against Urea and Creatinine Level in Male Wistar Rats on Ethylene Glycol Induced Nephrolithiasis.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 742-746. DOI: 10.5220/0010087107420746

in Bibtex Style

@conference{icosteerr18,
author={Marline Nainggolan and Kasmirul Rumlan Sinaga and Siti Morin Sinaga and Sony Eka Nugraha},
title={Effect of Ethanol Extract of Celery (Apium graveolens L) against Urea and Creatinine Level in Male Wistar Rats on Ethylene Glycol Induced Nephrolithiasis},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={742-746},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010087107420746},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Effect of Ethanol Extract of Celery (Apium graveolens L) against Urea and Creatinine Level in Male Wistar Rats on Ethylene Glycol Induced Nephrolithiasis
SN - 978-989-758-449-7
AU - Nainggolan M.
AU - Sinaga K.
AU - Sinaga S.
AU - Nugraha S.
PY - 2018
SP - 742
EP - 746
DO - 10.5220/0010087107420746