In Silico Analysis of Boron Derivate Compounds as Potential ER-α Inhibitor

Urip Harahap, Ginda Haro, Hari Purnomo, Denny Satria

2018

Abstract

Background :BornUSU I or Boronhafagama I (1,5-bis(4-hydroxyphenyl)-3-oxa-1,5-diaza-2,4- diboropentane-2,4-diol) and BornUSU II or Boronhafagama II (1-(4-hydroxynaphthalen-1-yl)-5-(4- hydroxyphenyl)-3-oxa-1,5-diaza-2,4diboropentane-2,4 diol) are boron derivate compounds which are boron neutron captured therapy (BNCT) candidates. Estrogen receptor alpha (ER-α) appear a crucial assignment in the growth and development of bone, breast and uterine pathology especially in human cancers, including breast cancer.Tamoxifen has been used as a cure for women who have been identified breast cancer for around four decades. Tamoxifen has high risks, such as the risk endometrial malignancy and hyperplasia varies from 1.5 to 6.9 fold after cumulative and long duration usage.

Paper Citation

in Harvard Style

Harahap U., Haro G., Purnomo H. and Satria D. (2018). In Silico Analysis of Boron Derivate Compounds as Potential ER-α Inhibitor.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 814-817. DOI: 10.5220/0010091808140817

in Bibtex Style

@conference{icosteerr18,
author={Urip Harahap and Ginda Haro and Hari Purnomo and Denny Satria},
title={In Silico Analysis of Boron Derivate Compounds as Potential ER-α Inhibitor},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={814-817},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010091808140817},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - In Silico Analysis of Boron Derivate Compounds as Potential ER-α Inhibitor
SN - 978-989-758-449-7
AU - Harahap U.
AU - Haro G.
AU - Purnomo H.
AU - Satria D.
PY - 2018
SP - 814
EP - 817
DO - 10.5220/0010091808140817