Single Nucleotide Polymorphism of MDR1 C1236T Gene and Its Association with Neutropenia Event in Breast Cancer Patients Treated by Chemoterapy

S. Syarifah, T. Widyawati, D. Hasni, D. R. Anggraini

2018

Abstract

Neutropenia event was one of the side effect which could be occurred in breast cancer patients receiving chemotherapy. MDR1 gene is a gene that encoded P-glycoprotein (P-gp), an active efflux pump for a variety of carcinogens and cytostatics. It has been suggested that MDR1 polymorphisms C1236T contribute to the variability of therapeutic outcome and side effects. The present study was conducted to investigate the association of C1236T polymorphisms in MDR1 gene with neutropenia incidence in breast cancer patients treated with antracycline based chemotherapy. As many as 144 Indonesian women’ isolated DNA samples were amplified using the PCR method. The analysis process of MDR1 C1236T polymorphism were done by using PCR-RFLP method. The frequencies of MDR1 C1236T genotype for homozygous CC, heterozygous CT and variant TT was 13 (9,03%), 93 (64,58%), and 38(26,39%) respectively. There was no association between MDR1 C1236T polymorphisms with neutropenia event (p > 0.05). However, 69 patients (47.9%) .suffered for neutropenia event. Limitation: the data of patients were collected only after 3 cycles of chemotherapy.

Paper Citation

in Harvard Style

Syarifah S., Widyawati T., Hasni D. and Anggraini D. (2018). Single Nucleotide Polymorphism of MDR1 C1236T Gene and Its Association with Neutropenia Event in Breast Cancer Patients Treated by Chemoterapy.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 833-836. DOI: 10.5220/0010092808330836

in Bibtex Style

@conference{icosteerr18,
author={S. Syarifah and T. Widyawati and D. Hasni and D. R. Anggraini},
title={Single Nucleotide Polymorphism of MDR1 C1236T Gene and Its Association with Neutropenia Event in Breast Cancer Patients Treated by Chemoterapy},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={833-836},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010092808330836},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Single Nucleotide Polymorphism of MDR1 C1236T Gene and Its Association with Neutropenia Event in Breast Cancer Patients Treated by Chemoterapy
SN - 978-989-758-449-7
AU - Syarifah S.
AU - Widyawati T.
AU - Hasni D.
AU - Anggraini D.
PY - 2018
SP - 833
EP - 836
DO - 10.5220/0010092808330836