Vitamin D and Its Association with Tumor Necrosis Factor-alpha Level in Active Tuberculosis Patients in North Sumatera, Indonesia

Dina Keumala Sari, Ridha Dharmajaya, Mutiara Indah Sari, Dewi Masyithah

2018

Abstract

Background: Mycobacterium tuberculosis is one of bacteria that caused tuberculosis disease. This disease related to macro and micronutrient deficiency, also to inflammation process. One of deficiency micronutrient is vitamin D deficiency, host cell response in including deficiency vitamin D, this would affect tumor necrosis factor (TNF)-alpha level. Objective: We sought to determine whether there is an association between vitamin D status and TNF-alpha status in active tuberculosis patients. Design: We conducted a crosssectional study of 25 man and women aged 18-60 years with active tuberculosis in North Sumatera, Indonesia. Parameters were 25(OH)D, TNF-alpha serum level, biomolecular parameters such as albumin and hsCRP also assessed. The association was analysis using chi-square or fischer test. Results: the mean of study subjects age were 37.2±14.9 years old, there were 81.2% subjects categorized into vitamin D deficiencyinsufficiency and 18.8% categorized into vitamin D sufficiency. All of the subjects had high TNF alpha level, There is an association between vitamin D and TNF alpha serum level. Conclusions: based on this result, there was an association between vitamin D and TNF-alpha serum level in active tuberculosis.

Paper Citation

in Harvard Style

Sari D., Dharmajaya R., Sari M. and Masyithah D. (2018). Vitamin D and Its Association with Tumor Necrosis Factor-alpha Level in Active Tuberculosis Patients in North Sumatera, Indonesia.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 856-860. DOI: 10.5220/0010095408560860

in Bibtex Style

@conference{icosteerr18,
author={Dina Keumala Sari and Ridha Dharmajaya and Mutiara Indah Sari and Dewi Masyithah},
title={Vitamin D and Its Association with Tumor Necrosis Factor-alpha Level in Active Tuberculosis Patients in North Sumatera, Indonesia},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={856-860},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010095408560860},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Vitamin D and Its Association with Tumor Necrosis Factor-alpha Level in Active Tuberculosis Patients in North Sumatera, Indonesia
SN - 978-989-758-449-7
AU - Sari D.
AU - Dharmajaya R.
AU - Sari M.
AU - Masyithah D.
PY - 2018
SP - 856
EP - 860
DO - 10.5220/0010095408560860