Vimentin Expression in Stem Cell-like Subtypes of Triple Negative Breast Cancer (TNBC)

Betty, Delyuzar

2018

Abstract

Triple negative breast cancers (TNBC) tested phenotypically negative for estrogen (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER-2). This cross-sectional study was performed on breast cancer patients in Haji Adam Malik Hospital Medan from 2013 to 2016. Data about demographics were extracted from patients’ records and histopathologic features were obtained using Hematoxylin Eosin (HE) and immunohistochemistry staining. By using CD44, CD24, Twist, Claudin7, and Vimentin, a total 67 breast tumor samples with TNBC were classified as 19 cases of stem-cell like and 48 non stem-cells like subtypes. Postmenopause women with tumor size more than 5cm, higher stage and grade histology were likely to have non stem-cells like subtypes. Women with mucinous carcinoma and metaplastic carcinoma of no special type tended to have non stem-cells like subtypes. Both stem-cells like and non stem-cells like subtypes commonly had low Vimentin. By using immunohistochemistry staining, TNBC can be differentiated into stem-cell like and non-stem-cell like subtypes. Stemness in stem cell like subtypes are resistant to therapy. Therefore, identification of stem-cells in TNBC needs special attention assist in more optimal handling

Paper Citation

in Harvard Style

Betty. and Delyuzar. (2018). Vimentin Expression in Stem Cell-like Subtypes of Triple Negative Breast Cancer (TNBC).In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 865-870. DOI: 10.5220/0010096408650870

in Bibtex Style

@conference{icosteerr18,
author={Betty and Delyuzar},
title={Vimentin Expression in Stem Cell-like Subtypes of Triple Negative Breast Cancer (TNBC)},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={865-870},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010096408650870},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Vimentin Expression in Stem Cell-like Subtypes of Triple Negative Breast Cancer (TNBC)
SN - 978-989-758-449-7
AU - Betty.
AU - Delyuzar.
PY - 2018
SP - 865
EP - 870
DO - 10.5220/0010096408650870