Histopathologic Feature and Vitamin D Receptor Expression of Benign Breast Tumor

Mega Sari Sitorus, Dwi Ritta Anggraini, Lita Feriyawati

2018

Abstract

Many studies say that vitamin D levels are useful as a protection that can decrease the risk of breast cancer, colon, prostate and ovarian cancers. But some say it's not related. But how the expression of benign breast tumor never been reported. The existence of VDR can be showed by its expression through immunohistochemistry. This report will describe the expression of VDR in benign breasst tumor which the most is fibroadenoma mamma. Pathological tissue samples were obtained from 50 patients suffered with benign breast lesion that treated in Grandmed Hospital. There are 50 females, the mean age was 24,1, ranging from 12 to 42 years of age. All of the Hematoksilin Eosin staining slides are examined by pathologist using light microscope and concluded as fibroadenomas. The presence and location VDR is detected by immunostaining with VDR Antibody (D-6) from Santa Cruz Biotechnology. One of the most common benign tumors in the breast around 30 years old is fibroadenomas. In this study it is found that 34 patients (68%) under 30 years old. The expression of VDR in the fibroadenomas are strong : 42 tumours (82%), moderate: 4(8%, low: 3 (6%), negative: 1(2%). Most of them are VDR positif expression. From the figure 4 we can see that the VDR is placed in the nuclear dan cell membrane of the cells. Stromal cells doesn’t show expression of VDR. This discribe that only epithelial cell of breast glandular this receptor.

Paper Citation

in Harvard Style

Sitorus M., Anggraini D. and Feriyawati L. (2018). Histopathologic Feature and Vitamin D Receptor Expression of Benign Breast Tumor.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 880-883. DOI: 10.5220/0010098208800883

in Bibtex Style

@conference{icosteerr18,
author={Mega Sari Sitorus and Dwi Ritta Anggraini and Lita Feriyawati},
title={Histopathologic Feature and Vitamin D Receptor Expression of Benign Breast Tumor},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={880-883},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010098208800883},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Histopathologic Feature and Vitamin D Receptor Expression of Benign Breast Tumor
SN - 978-989-758-449-7
AU - Sitorus M.
AU - Anggraini D.
AU - Feriyawati L.
PY - 2018
SP - 880
EP - 883
DO - 10.5220/0010098208800883