Effect of Lawsonia inermis Linnaeus Leaf Ethyl Acetate Extract on Liver in Normal Rat

Tri Widyawati, Siti Syarifah, Dwi Ritta Anggraini

2018

Abstract

Previous study revealed the antihyperglycemic activity and hepatoprotective effect of Lawsonia inermis Linn. leaf extract (EAE) dose 1 g/kgbw in streptozotocin-induced diabetic rats. The present study was conducted to evaluate the toxic effect of EAE on hepar in normal rat. EAE was obtained by serial extraction using n-hexane and ethyl acetate (EAE). Two groups of Wistar rats (n=5) were treated with EAE (1.25 g/kgbw) and distilled water (NC: 10 ml/kgbw), orally, daily for 14 days, respectively. After 14 days the rats were sacrified for histopathological evaluation of liver using hematoxyilline-eosin staining.The result showed normal apperance of liver in NC-treated rat, contrarily in EAE-treated rats showed the hydrophic degeneration, sinusoid and central vein congestion. Multiple nodules with strict lines, consisted of fat cells undergoing proliferation, monocytes and limphocytes infiltration were also found. These results suggest that EAE dose 1.25 g/kgbw toxic to liver and potentially destroy its function.

Paper Citation

in Harvard Style

Widyawati T., Syarifah S. and Anggraini D. (2018). Effect of Lawsonia inermis Linnaeus Leaf Ethyl Acetate Extract on Liver in Normal Rat.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 911-913. DOI: 10.5220/0010100909110913

in Bibtex Style

@conference{icosteerr18,
author={Tri Widyawati and Siti Syarifah and Dwi Ritta Anggraini},
title={Effect of Lawsonia inermis Linnaeus Leaf Ethyl Acetate Extract on Liver in Normal Rat},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={911-913},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010100909110913},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Effect of Lawsonia inermis Linnaeus Leaf Ethyl Acetate Extract on Liver in Normal Rat
SN - 978-989-758-449-7
AU - Widyawati T.
AU - Syarifah S.
AU - Anggraini D.
PY - 2018
SP - 911
EP - 913
DO - 10.5220/0010100909110913