Differences in Caspase-3 Expressions of Liver Organs and Spleen in Animals Model Rattus Norvegicus Infected with Candida Albicans and Candida Non Albican Fungus

Yanuar Kristanto, Willy Sandhika, Agung Dwi Wahyu Widodo

2018

Abstract

Invasive candidiasis is an opportunistic infection as the leading cause of morbidity and mortality in immunocompromised patients. Candida albicans is the dominant species causing all cases of invasive candidiasis. However, other species namely Candida Non Albicans also play a role. High-grade Caspase signifies the hemeostasis system can not maintain the organ system causing multiple organ dysfunction syndrome (MODS). Caspase-3 plays a role in the process of apoptosis in extrinsic processes. The aim of this study was to look at caspase-3 expression in the liver and lien of experimental animals of Rattus norvegicus indicating the severity of Candida albicans infection and Candida non albicans. The healthy rats were randomly selected and injected the peritoneum in quadrant 3 to 1 ml (PZ, Suspension C. Albicans, C. Non Albicans) in each group of experimental animals. Mice were observed for 24 hours. After 24 hours of surgery for the removal of liver and liver organ. The organ tissue of the mouse was fixed into the formalin buffer and tissue preparation was performed for Caspase-3 Immunohistochemistry. The median values ​​of the Caspase-3 liver index of C. albicans leprosy group (12.5), C. Non Albicans (10), and the control group (9.5) median value of caspase-3 organ index of C. albicans (31), C. Non Albicans group (28.5), and control group (4).

Paper Citation

in Harvard Style

Kristanto Y., Sandhika W. and Widodo A. (2018). Differences in Caspase-3 Expressions of Liver Organs and Spleen in Animals Model Rattus Norvegicus Infected with Candida Albicans and Candida Non Albican Fungus.In Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS, ISBN 978-989-758-348-3, pages 263-268. DOI: 10.5220/0007541102630268

in Bibtex Style

@conference{icps18,
author={Yanuar Kristanto and Willy Sandhika and Agung Dwi Wahyu Widodo},
title={Differences in Caspase-3 Expressions of Liver Organs and Spleen in Animals Model Rattus Norvegicus Infected with Candida Albicans and Candida Non Albican Fungus},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,},
year={2018},
pages={263-268},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007541102630268},
isbn={978-989-758-348-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,
TI - Differences in Caspase-3 Expressions of Liver Organs and Spleen in Animals Model Rattus Norvegicus Infected with Candida Albicans and Candida Non Albican Fungus
SN - 978-989-758-348-3
AU - Kristanto Y.
AU - Sandhika W.
AU - Widodo A.
PY - 2018
SP - 263
EP - 268
DO - 10.5220/0007541102630268