Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province

Frieti Vega Nela, Heny Arwati, Yoes Prijatna Dachlan

2018

Abstract

Introduction. Annual parasite incidence (API) in East Nusa Tenggara Province (NTT) 2015 per 1000 population is 7.04%. However, API in each Public Health Center (Puskesmas) Sumba Island remains high. High levels of pro-inflammatory cytokines in malaria infection, such as TNF-α is associated with severe pathology, whereas, anti-inflammatory cytokines such as IL-10 is associated with acute malaria. The objective of the study was to analyze correlation between parasite densities and plasma level of both cytokines in P. vivax-infected patients in East Sumba Regency East Nusa Tenggara Province. Methods. Parasite densities were calculated per 500 leucocytes on Giemsa-stained thick blood smears. The levels of TNF-α and IL-10 were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical analyses were done by Spearman test. Results. Correlation was observed significantly in parasite density and TNF-α p = 0.032 and parasite density and IL-10 p=0.000. This result indicated that the stage of immunity in patients was not affected by the parasite density but clinical symptoms may have a greater role in increasing and decreasing the plasma level of cytokines. Conclusion. There was correlation between parasite densities and plasma level of TNF-α and IL-10 in P. vivax infected patients is the studied areas.

Paper Citation

in Harvard Style

Nela F., Arwati H. and Dachlan Y. (2018). Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province.In Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS, ISBN 978-989-758-348-3, pages 325-328. DOI: 10.5220/0007542203250328

in Bibtex Style

@conference{icps18,
author={Frieti Vega Nela and Heny Arwati and Yoes Prijatna Dachlan},
title={Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,},
year={2018},
pages={325-328},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007542203250328},
isbn={978-989-758-348-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,
TI - Correlation of Parasite Density with Plasma Level of TNF-α and IL-10 in Patients Infected by Plasmodium Vivax in East Sumba District, East Nusa Tenggara Province
SN - 978-989-758-348-3
AU - Nela F.
AU - Arwati H.
AU - Dachlan Y.
PY - 2018
SP - 325
EP - 328
DO - 10.5220/0007542203250328