Effect of Nigella Sativa Extract on Bacteriology Parameter of Multibacillar Leprosy Patients Administering MDT-WHO: Three Months Observation

Dian Kusuma Dewi Ramadhani, Renni Yuniati, Subakir, Asih Budi Astuti, Falah Faniyah, Prasetyowati Subchan

2018

Abstract

MDT-WHO implementation has decreased leprosy global prevalence. However, number of new cases detected is still high. Therefore, new appropriate strategy, besides early detection and WHO-MDT treatment which are the main strategies in leprosy eradication, is needed. The aim of this study was to investigate the effects of Nigella sativa extract on bacteriology parameters of multibacillar leprosy patients administering MDT-WHO. It was Double Blind - Randomized Controlled Trial study which was conducted in Jepara, Central Java Province, Indonesia during February to June 2016. This study was performed on 60 eligible multibacillar leprosy patients administering MDT-WHO. Bacterial index (BI) was measured using Ridley logarithmic scale, whereas morphology index (MI) was measured as percentage of solid bacteria to the all forms of bacteria. There was no subject who dropped out. The characteristics of subjects were similar between the two groups, except for the MDT duration at baseline, where MDT duration in control group was longer. There was no significant difference in BI proportion and MI proportion in the two groups after treatment. Average BI in month 2 and 3 tend to be lower than control although not statistically significant. There were significant differences of average BI decline between control and treatment groups in month 2 (p=0.000) and month 3(p=0.005). There were statistically significant differences of average MI and average MI decline between control and treatment groups in month 1 (p=0,000, p= 0.001, respectively). This study demonstrated that Nigella sativa extract affected average MI and BI decline differences. Its efficacy as adjuvant therapy might be confounded by duration of MDT-WHO.

Paper Citation

in Harvard Style

Ramadhani D., Yuniati R., Subakir., Astuti A., Faniyah F. and Subchan P. (2018). Effect of Nigella Sativa Extract on Bacteriology Parameter of Multibacillar Leprosy Patients Administering MDT-WHO: Three Months Observation.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 9-13. DOI: 10.5220/0008149600090013

in Bibtex Style

@conference{rcd18,
author={Dian Kusuma Dewi Ramadhani and Renni Yuniati and Subakir and Asih Budi Astuti and Falah Faniyah and Prasetyowati Subchan},
title={Effect of Nigella Sativa Extract on Bacteriology Parameter of Multibacillar Leprosy Patients Administering MDT-WHO: Three Months Observation},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={9-13},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008149600090013},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Effect of Nigella Sativa Extract on Bacteriology Parameter of Multibacillar Leprosy Patients Administering MDT-WHO: Three Months Observation
SN - 978-989-758-494-7
AU - Ramadhani D.
AU - Yuniati R.
AU - Subakir.
AU - Astuti A.
AU - Faniyah F.
AU - Subchan P.
PY - 2018
SP - 9
EP - 13
DO - 10.5220/0008149600090013